IndraLab

Statements

USP9X deubiquitinates MIB1. 3 / 3
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"Further, in human breast cancer cell lines, USP9X deubiquitinates and stabilizes MIB1, an activator of ligand dependent canonical NOTCH1 signaling that is important for cardiac development."
33547080
reach
"Therefore, we postulated that nitrosylated USP9X deubiquitinates and stabilizes MIB1 in valvular interstitial cells, which potentiates the ability of a ligand producing cell to activate NOTCH on a neighboring cell."
33547080
ubibrowser
"USP9x in turn stimulates JAG1 activity through two mechanisms: (1) through TRB3 deubiquitination and stabilization, and (2) through deubiquitination and activation of Mind Bomb 1, an E3 ligase required for JAG1 ubiquitination-mediated endocytosis and Notch activation."
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