IndraLab

Statements

TP53 binds mutated MDM2. 4 / 4
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"The second blind test contains the mutations of the MDM2 and p53 complex (PDB ID : 1YCR) provided by Geng etal."
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"Cotransfecting these cells with a mutant Mdm2, which can bind to p53 but can not target it for degradation, resulted in higher p53 levels than that in cells transfected with wildtype Mdm2, even in the presence of the anoikis promoting fibronectin fragment."
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"Interestingly, our western blot data in XREF_FIG showed that the mutant Mdm2, which can bind to p53 but can not target it for degradation, gave the expected mutant Mdm2 band at the 37 KD position but also some high molecular weight bands."
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"Finally, we transfected p53 and Mdm2-null cells with wildtype p53, wildtype Mdm2 and a mutant Mdm2 (human Mdm2 Delta222-437) that binds p53 but can not target it for proteasomal degradation [XREF_BIBR, XREF_BIBR], or a combination of these."
20577896