IndraLab

Statements

MTOR phosphorylates RPS6KB1-S6K. 18 / 18
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"Phosphorylation of p70 S6K is mediated by mTOR, and thus can be used to validate mTOR activation."
20445056
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"Here, we show that RAFT1 directly phosphorylates p70 (S6k), 4E-BP1, and 4E-BP2 and that serum stimulates RAFT1 kinase activity with kinetics similar to those of p70 (S6k) and 4E-BP1 phosphorylation."
9465032
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"MTOR has been shown to phosphorylate p70 S6K directly in vivo and in vitro (Brown et al., 1995; Saitoh et al., 2002)."
12553669
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"FRAP also is shown to phosphorylate PP2A in vitro, consistent with a model in which phosphorylation of PP2A by FRAP prevents the dephosphorylation of 4E-BP1 and p70 (s6k), whereas amino acid deprivation or rapamycin treatment inhibits FRAP 's ability to restrain the phosphatase."
10200280
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"Finally, it has been demonstrated that the activation of mTOR via the overexpression of Rheb, a direct activator of mTOR, is sufficient to induce an increase in p70 S6k phosphorylation, cap dependent translation and protein synthesis in skeletal muscles with normal activity."
26092121
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"Insulin induced PI-3K pathway activates FK506 binding protein-rapamycin-associating protein or mammalian Target of Rapamycin (FRAP and mTOR) which in turn phosphorylates translational eukaryotic initi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26321373
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"66 In response to PI3K and Akt signaling, mTOR rapidly phosphorylates both p70 s6k and 4EBP1, the latter leading to release of eIF4E, resulting in initiation of translation; these actions of mTOR can [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12819026
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"Additionally, mTOR can induce the phosphorylation of p70S6 kinase (S6K), which also promotes HIF-1α protein synthesis [13]."
34360716
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"Activation of mTOR increases phosphorylation of p70 S6K, which activates ribosomal protein S6 (rpS6), a substrate of p70 S6K."
19442266
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"Similarly, we find in those Egf kidneys with significant renal fibrosis that loss of NCC is associated with increased renal active β-catenin levels and activation of mTOR signaling targets with increased phosphorylation of 4E-BP1 (Thr37/46) and p70 S6K (Figure 2)."
35442545
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"Furthermore, mTOR phosphorylates p70 S6K to stimulate translation of 5 ' terminal oligopyrmidine tract (5 ' TOP) mRNAs that encode ribosomes and translation factors, thus increasing the translational capacity of the cell 23."
22267161
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"Under high nutrient availability, mTOR is stimulated and promotes eIF4E binding protein (4E-BP1) and p70 S6K phosphorylation to activate translation initiation."
23160380
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"While it was well-known that these other family members responded to DNA damage, we have recently shown that UV induces FRAP accumulation in the nucleus of keratinocytes, and that the induced FRAP inc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12427541
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"RAFT1 phosphorylates p70 (S6k) much more effectively than 4E-BP1, and the phosphorylation sites on the two proteins show little homology."
9465032
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"In this instance, p70 S6K is phosphorylated by mTOR acting as an ' ATP sensor ' in response to a rise in beta-cell ATP levels caused by increased glucose metabolism [95]."
12127723
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"Our studies and those of others on the molecular mechanisms underlying the observed sensitization to apoptosis revealed an inhibition of both mTOR- and MEK and ERK mediated phosphorylation of the kinase p70 S6K at required sites for activation, as well as down-regulation of the cell cycle regulated proteins cyclin D2 and D3."
22348393
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"No interaction with or phosphorylation of p70 S6k or 4E-BP1 by FRAP has been observed, suggesting the existence of as yet unidentified components of this pathway."
8752206
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"In hippo campal neurons, increased intracellular Ca 2+ levels through intracellular stores increased mTOR dependent phosphorylation of p70 S6K, linking intracellular Ca 2+ levels with mTOR activation [XREF_BIBR, XREF_BIBR], and suggests that in these neurons, lithium will lead to an mTOR dependent activation of macroautophagy."
22924509