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CTNNB1 bound to FLYWCH1 inhibits CTNNB1. 1 / 1
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"Using a modified yeast-2-hybrid based Ras-Recruitment system, it is demonstrated that FLYWCH1 directly binds to unphosphorylated (nuclear) beta-catenin efficiently suppressing the transcriptional activity of Wnt and beta-catenin signaling that can not be rescued by TCF4."