IndraLab

Statements


Tyrosine-phosphorylated EGFR binds GRB2. 3 / 3
| 2 1
trips
"These analyses reveal a hierarchy of interactions between Grb2 and Shc with the EGFR and indicate that Grb2 can bind the tyrosine-phosphorylated EGFR directly, as well as indirectly via Shc."
trips
"Immunoblotting experiments indicate that GRB2 associates with tyrosine-phosphorylated epidermal growth factor receptors (EGFRs) and platelet-derived growth factor receptors (PDGFRs) via its SH2 domain."
reach
"In support of this model, Gab2 mutants defective in 14-3-3 binding exhibit increased recruitment of Grb2 and consequently sustained association with the tyrosine phosphorylated EGFR and Shc."