IndraLab

Statements

TGFA binds EGF, EGFR, and AREG. 14 / 14
| 14
sparser
"These include: EGF, TGFα and amphiregulin (AREG), which bind specifically to EGFR; heparin-binding EGF-like growth factor, betacellulin and epiregulin which bind to both EGFR and ErbB4 [ xref ]; and the neuregulins/heregulins (HRGs), which are specific for ErbB3 and ErbB4 [ xref ]."
20840765
sparser
"From those ligands, EGF, transforming growth factor alpha and amphiregulin bind specifically to EGFR [ xref ]."
23962910
sparser
"TGF-α, amphiregulin, and EGF specifically bind EGFR."
24728052
sparser
"There is a family of EGF ligands of which EGF, TGFα and AREG exclusively bind the EGF receptor (EGFR)."
33445520
sparser
"EGF, TGF-α and amphiregulin bind specifically to EGFR."
22416774
sparser
"EGF, AR and TGFα bind EGFR; HRG, BTC and HB-EGF bind EGFR and erbB-4 ( xref )."
25619714
sparser
"EGF, transforming growth factor-alpha and amphiregulin bind exclusively to erbB1[ xref ]."
18691415
sparser
"However, only EGF, AREG and TGF-α bind EGFR exclusively; other ligands also bind other ERBB family receptors [ xref , xref , xref ]."
27835572
sparser
"Epidermal growth factor receptor binds primarily to EGF, transforming growth factor-a, and amphiregulin growth factors, while HER3 and HER4 bind HRG and its isoforms."
11706393
sparser
"Although AREG, EGF and TGF-α bind exclusively to EGFR, they have diverse functions and can act either redundantly or differentially."
25869072
sparser
"The EGF-like ligands include EGF, amphiregulin, and transforming growth factor alpha (TGFα), which only bind to the EGF receptor (EGFR), and heparin binding EGF (HB-EGF), betacellulin, and epiregulin, which bind to both EGFR and ErbB4."
21381079
sparser
"Whereas EGF, TGF-α and amphiregulin bind to ErbB1, the heregulins (HRGs; also known as neuregulins) bind ErbB3 and ErbB4 [ xref , xref ]."
27447549
sparser
"For example, EGF, TGF-α and AREG specifically bind to the EGFR, whereas BTC, HB-EGF and EREG bind to both EGFR and HER4."
21658434
sparser
"Ligands for HER receptors can be divided into three groups [ xref ]: the first includes EGF, amphiregulin and TGF-α, which bind specifically to HER1; and the second includes heparin-binding EGF, betacellulin and epiregulin, which show dual binding specificity with both HER1 and HER4."
32002122