IndraLab

Statements


TP53-R175H activates apoptotic process. 2 / 2
| 2

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"This is consistent with data showing that brief exposure of R175H mutant p53 to Zn 2+ is sufficient to induce mutant p53 reactivation and apoptosis (Yu et al, 2018)."

reach
"ZMC1 raises intracellular Zn 2+ levels to return p53 R175H mutant (zinc deficient) to " Wt-like-p53 " conformation via the recombination of Zn 2+ and p53 R175H, which induces apoptosis in murine cell lines and significantly increases the median survival of KPC mice model."