IndraLab

Statements

UCHL1 increases the amount of TYMS. 4 / 4
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"Mechanistically, UCHL1 promoted PEM resistance in NSCLC by upregulating the expression of thymidylate synthase (TS), based on reduced TS expression after UCHL1 inhibition and re-emergence of PEM resistance upon TS restoration."
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"Furthermore, we revealed that UCHL1 upregulated the expression of TS, which promotes cell cycle progression and DNA repair, thereby conferring resistance to PEM and other drugs."
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"Therefore, UCHL1 may indirectly promote the transcription of TS by targeting other enzymes or proteins, such as HIF-1alpha and mTOR, and further studies are needed to explore this topic."
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"Furthermore, UCHL1 upregulated TS expression, which mitigated PEM induced DNA damage and cell cycle arrest in NSCLC cells, and also conferred resistance to PEM and other drugs."
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