IndraLab

Statements

RAS activates phosphorylated ERK. 9 / 9
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"Both MAPK and PI3K-AKT signaling pathways are downstream of Ras, since inhibition of Ras abolishes the circadian rhythm of pERK and pAKT, while inhibition of cAMP signaling dampens the circadian rhythm of Ras activity."
22371971
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"Together, these data support a signal transduction pathway during in vitro conditioning in which PKCzeta activates MEK directly or through Ras and Raf to potentiate the function of p-ERK."
18809472
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"As expected, both PIK3CA and RAS increased phospho-AKT (pAKT S473) and phospho-S6 (pS6) levels, and RAS increased phospho-ERK (pERK) with limited variations in the levels of S6, AKT, and ERK proteins."
25099740
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"In contrast, depletion of the WT Ras isoforms increased pERK in MIA PaCa-2 and RD cells, suggesting that WT Ras may antagonize mutant Ras and ERK signaling."
23319767
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"Although overexpression of ERRB2 led to increased metastatic potentials in PC3 cells and DU145 cells, overexpression of H-RAS did not have similar effects on these two cell lines or the LnCaP cell line (XREF_FIG and XREF_FIG), despite the fact that RAS overexpression did elevate p-ERK (particularly p-ERK1) as well as p-AKT and/or p-p38 in all of the three human prostate cancer cell lines (XREF_FIG)."
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"As expected, both PIK3CA and RAS increased phospho-AKT (pAKT S473) and phospho-S6 (pS6) levels, and RAS increased phospho-ERK (pERK) with limited variations in the levels of S6, AKT, and ERK proteins."
25099740
eidos
"These results demonstrated that PDGF-AA increased pERK , probably by activating RAS ."
36109592
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"Direct RAS activation in CIAR-MCF10As elicits a rapid increase in phospho-ERK, whereas, in CIAR-293s, this increase is more gradual."
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"These findings were further confirmed in IF studies in which the presence of active Ras restored pERK accumulation in the nucleus of DU145-Sef cells (XREF_FIG)."
19888221