IndraLab

Statements

EGF increases the amount of CCND1. 11 / 18
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"DHT and EGF up-regulated cyclinD1 (CD1) at both mRNA and protein levels in A549 cells"
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"Levels of cyclin D1 protein were elevated following 3 h arsenic and EGF (Fig. 2A, row 1 CCND1). The positive control, EGF also induced a large increase in cyclin D1 levels."
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"Both EGR1 and CCND1 mRNA expression were upregulated by about 1.5 fold in U251 cells and U251SLCs by EGF."
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"In line with this, we recently found that flotillins are needed for cyclin D1 expression, since a knockdown of flotillin-1 in HeLa cells resulted in a reduced basal as well as EGF-induced cyclin D1 expression [13] and also in an arrest of the cell cycle in G1 (our unpublished observations), indicating that flotillins are needed for a sustained signaling downstream of ERK1/2."
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"PKM2-dependent histone H3 modification serves an important role in EGF-induced cyclin D1 and c-Myc expression, glioma cell proliferation, cell cycle progression and brain tumorigenesis ( xref )."
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"In addition, rH3-T11A expression abrogated EGF enhanced mRNA levels of CCND1 and MYC (XREF_FIG), H3-K9 acetylation, and expression of cyclin D1 and c-Myc in both U87 and EGFR (XREF_FIG) and U251 (XREF_SUPPLEMENTARY) cells."
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"We previously reported that EGF and PGE 2 alone induced the transcription of the nuclear EGFR-target genes CCND1, PTGS2, MYC and NOS2, with a maximal activation at 2 h and 4 h, respectively [XREF_BIBR]."
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"Our previous study demonstrated that TIP30 regulated EGF-dependent cyclin D1 transcription in human lung adenocarcinoma and suppressed tumorigenesis."
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"This reflected the observed EGF induced increase in CCND1 mRNA expression (XREF_FIG), occurring irrespective of TIMP1 expression (XREF_FIG) as a confirmation of its separation from invasion signalling."
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"Moreover, immunoblotting and real-time PCR analyses showed that depletion of PFKP inhibited EGF-induced transcription of CCND1 and MYC ( xref and xref ) and their protein expression ( xref and xref ) in U87/EGFR, LN229, and A549 cells."
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"In line with this finding, reconstituted expression of rCdc25A Y59F mutant inhibited EGF enhanced mRNA (XREF_SUPPLEMENTARY) and protein expression (XREF_FIG) of CCND1 and MYC and c-Myc-upregulated GLUT1, PKM2 and LDHA."
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