IndraLab

Statements

RNF2 binds TP53 and MDM2. 7 / 7
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sparser
"Importantly, we found that RNF2 directly binds with both p53 and MDM2 and promotes MDM2-mediated p53 ubiquitination."
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sparser
"RNF2 directly binds with p53 and MDM2, and promotes MDM2-mediated ubiquitination."
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sparser
"When examining the interaction between RNF2, p53 and MDM2, we found that RNF2 can bind with both p53 and MDM2 to form a ternary complex."
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reach
"Notably, the existence of the RNF2, p53, and MDM2 complex was also detected under normal conditions (XREF_FIG)."
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sparser
"In the same overexpression system, we also found that RNF2 binds with both p53 and MDM2 to form a ternary complex ( xref )."
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sparser
"RNF2 can bind with both p53 and MDM2 to form a ternary complex ( xref ), suggesting that RNF2 might also be a regulator of MDM2."
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sparser
"We also investigated a possible mechanism to explain the effect of RNF2 on p53 and found that RNF2 directly binds with both p53 and MDM2."
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