IndraLab

Statements


MDM2 bound to proteins inhibits TP53. 2 / 2
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"On one hand, these ribosomal proteins bind MDM2 and inhibit the E3 ubiquitin ligase activity resulting in stabilization of p53."

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"The released ribosomal proteins bind to MDM2 to block its ubiquitinylation of p53, leading to p53 stabilization and subsequent induction of p53 mediated G 1 cell cycle arrest or apoptosis."