IndraLab

Statements

RPS6KB1-S6K activates RPS6. 5 / 5
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"Activation of mTOR increases phosphorylation of p70 S6K, which activates ribosomal protein S6 (rpS6), a substrate of p70 S6K."
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"The only kinase known to be activated directly by mTORC1 is p70 S6K, which subsequently activates ribosomal S6 protein (S6)."
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"One major substrate of rapamycin sensitive mTORC1 complex is p70 S6K, whose phosphorylation at Thr 389 activates the ribosomal protein S6 via phosphorylation at Ser 235/236 and Ser 240/244 [12]."
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"Moreover, it is suggested that full activation of p70 S6K is dependent on the provision of amino acids to elicit a downstream activation of rpS6 [XREF_BIBR, XREF_BIBR]."
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"Although inhibition of p90 RSK had no effect on either P-rpS6 or P-4E-BP1, inhibition of p70 S6K selectively reduced P-rpS6."
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