IndraLab

Statements

RHEB binds MTOR and GAPDH. 3 / 3
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"We explored the impact of GAPDH-Rheb binding upon mTOR signaling."
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"GAPDH interaction with rheb, the activator of mTOR, mitigates mTOR-C1 signaling pathway thus halting the growth mechanism under conditions of energy depletion or inadequate glycolysis."
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"Our co-immunoprecipitation experiments showed that this was not the mechanism for fructose-induced mTORC1 activation, since Rheb-GAPDH and Rheb-mTOR interactions were not affected in the livers of fructose-supplemented rats [ xref ]."
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