IndraLab

Statements


Okadaic acid decreases the amount of IRS1. 5 / 5
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"According to the results of XREF_FIG, OA could reduce the expression of NF-kappaB protein and directly increase the expression of IRS1."

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"Meanwhile, OA decreased NF-kappaB protein expression and upregulated IRS1 and GLUT4 protein expression."

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"To illustrate the point that OA could relieve the expression of the IRS1 and GLUT4 by blocking the expression of NF-kappaB, PDTC was used to block NF-kappaB in our study."

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"Based on the above knowledge, we speculated that OA can relieve insulin resistance by directly affecting the expression of IRS1 protein."

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"Moreover, OA reduced the levels of TNF-alpha and IL-6 and upregulated IRS1 and GLUT4 protein expression."