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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

MDM2 bound to MDM4 activates TP53. 2 / 2

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"Together, these data suggest that antagonism of endogenous Mdm2 and Mdmx heterodimers should activate endogenous p53."

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"In response to DNA damage ATM phosphorylates and modulates the function of several E3-Ubiquitin ligases, among which the MDM2 and MDM4 complex, whose activity and stability is downregulated by ATM, allowing in turn the stabilization of p53 (reviewed in)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...