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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

CDK4 bound to Cyclin inhibits RB1. 1 / 1

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"Cyclin D1, a gene with established oncogenic activity, binds and activates cyclin dependent kinases CDK2 and CDK4, which in turn phosphorylate and inactivate Rb allowing entry into S phase of the cell cycle and proliferation."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...