IndraLab

Statements

TP53 binds ZNF668 and MDM2. 6 / 6
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sparser
"These results identified the interaction domain of ZNF668 required for the interaction between MDM2, p53, and ZNF668 and indicated the importance of the nucleolar localization of ZNF668 for its interactions with MDM2 and p53."
21852383
sparser
"The interactions between ZNF668, p53, and MDM2 were further confirmed by reciprocal immunoprecipitation using ZNF668, p53, and MDM2 antibodies ( xref ), supporting the physical interactions among these three proteins in cells."
21852383
sparser
"Our findings further suggest that ZNF668 regulates MDM2 through a direct interaction between ZNF668 and MDM2-p53 complex since ZNF668 interacted with MDM2 and p53 in vivo and in vitro and since ZNF668 interfered with the MDM2-p53 interaction."
21852383
sparser
"We found that addition of purified ZNF668 protein decreased MDM2-p53 binding in a dose-dependent manner ( xref )."
21852383
sparser
"Since ZNF668 binds to MDM2 and p53, we next sought to determine whether there is a causal relationship between ZNF668 status and p53 protein levels."
21852383
sparser
"ZNF668 interacts with MDM2 and p53."
21852383