IndraLab

Statements

TGFB bound to TGFBR1 activates SMAD3. 4 / 4
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"The binding of TGF-β to its receptors TGFR1 and TGFR2 activates Smad2 and Smad3 through direct phosphorylation."
31817513
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"TGF-β binds to a heteromeric complex of transmembrane serine/threonine kinases, the type I and type II receptors ALK5 and TβRII, which phosphorylate and activate the TGF-β-specific intracellular signaling mediators Smad2 and Smad3."
21586099
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"Binding of TGFβ to TGFBR1 and TGFBR2 leads to direct phosphorylation and activation of receptor-regulated SMAD (R-SMAD) proteins, SMAD2 and SMAD3."
31721529
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"TGF-β binds to a heteromeric complex of transmembrane serine/threonine kinases, the type I and type II receptors, activin receptor-like kinase 5 (ALK5) and transforming growth factor-beta receptor type II TβRII, which phosphorylate and activate the TGF-β specific intracellular signaling mediators Smad2 and Smad3."
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