IndraLab

Statements

TNF activates phosphorylated ERK. 22 / 22
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"TNF-alpha treatment increased pERK in small- and medium sized DRG neurons and to a lesser degree in large neurons."
16508545
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"TNF treatment caused an increase in p-ERK in differentiating myoblasts, which was accompanied with reduced MyoD and MyoG levels, as well as reduced MyHC protein content."
34572540
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"However, Digibind could attenuate or reduce TNFalpha induced endothelial adhesion molecule expression, but had no effects on TNFalpha induced pERK upregulation."
19148111
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"TNF-alpha and/or TGF-alpha stimulation increased phospho-MEK and phospho-ERK in cells transfected with TNFR1 siRNA."
19628074
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"Regional application of TNF-α at a nerve root causes pain hypersensitivity and increases pERK in small and medium DRG neurons [56]."
33355900
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"In contrast, neither the steady-state levels nor the TNF-alpha or IL-1beta induction of pJNK or pERK were affected by culturing RA synovial fibroblasts with 3 muM lovastatin."
16774691
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"Similarly, the protein levels of p-JNK, JNK, p-ERK1/2, and ERK1/2 were relatively stable in hNPCs treated with TNF-alpha for different durations."
29622770
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"Also, TNF-alpha treatment increased p-p38 and p-ERK, and pretreatment of NMA reduced this increased expression of p-p38 and p-ERK."
22815072
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"Artemisinin significantly inhibited the protein level of phosphorylated ERK1/2 and p38 MAPK induced by TNF-alpha in the HUVECs at all concentrations tested, while the inhibition of the phosphorylation of JNK was only observed at the high concentrations (100 and 200 microM) (XREF_FIG)."
27122190
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"Besides, we demonstrated that TNF-alpha treatment induced a time dependent increase of p-ERK, peaking at 5min and then decreasing to a steady level that remained higher than in unstimulated cells up to 120min, as revealed by MFI and by western blot analyses."
33654147
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"The results clearly show that phospho-ERK is enhanced after acute BDNF treatment for 10 min and is further increased by 48 hours of TNF-α pre-treatment (Figure 9B, 9E)."
21958434
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"TNFalpha stimulation significantly increased phospho-ERK in IB3-1 at 30 min (p = 0.04)."
21992677
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"Prevention of TNFalpha induced pERK and NF-kappaB signaling abrogates the TNFalpha induced decrease in aquaporin 3 mRNA expression."
29038361
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"Mechanistically, MADD siRNA inhibited TNFalpha induced activation of pERK, pGSK3beta and beta-catenin, suggesting that MADD knockdown might exert its anti-migratory and invasive effects, by blocking TNFalpha/ERK/GSK3beta axis."
30760700
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"Icariin treatment resulted in a reduced expression of p-P38 and p-ERK signal activation induced by TNF-alpha and IFN-gamma; however, only SB203580, the p38 alpha/beta inhibitor, inhibited the secretion of inflammatory cytokines induced by TNF-alpha and IFN-gamma in cultured HaCaT cells."
26507164
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"Topical application of TNF-alpha to rat nerve root increased pERK in ipsilateral dorsal root ganglion (DRG) neurons and glia within 5 hours."
16508545
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"Instead of inhibiting C3a or TNF induced p-ERK1/2, pre-treatment with manumycin A directly resulted in a robust increase in p-ERK1/2."
30261438
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"To determine whether the different patterns of pERK required newly synthesized proteins, cells were treated with cycloheximide and TNFalpha."
19789336
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"AP-activated TNF-α induces ALI via p-JNK/MAPK and p-ERK/MAPK in the lung, while p38MAPK can be activated by a variety of extracellular stimuli, such as inflammatory mediators, heat injury, and ultraviolet light."
34497676
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"In MDA-MB-231 cells, level of p-p38 expression was up-regulated, while no significant change of p-JNK and p-ERK expression when cells were treated with same amount of TNF-alpha."
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"DLD-1, DKs8, and DKs8-kdN had elevated pERK signals when treated with cycloheximide and TNFalpha, compared to TNFalpha alone (XREF_FIG)."
19789336
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"TNF-alpha induced a significant enhancement of p-ERK1/2, and an upregulation of mRNA and protein of Egr-1."
29367088