IndraLab

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USP16 inhibits PRC1. 2 / 2
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"Interestingly, USP16, which is located on human chromosome 21 and triplicated in Down 's syndrome, reduces the self-renewal of hematopoietic stem cells and the expansion of mammary epithelial cells, neural progenitors and fibroblasts in mice, suggesting that Usp16 may antagonize PRC1 function in the self-renewal and/or senescence pathways 31."
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"Since Bmi1 is known to be critical for the maintenance of neural progenitors XREF_BIBR, XREF_BIBR, XREF_BIBR, we hypothesized that an extra copy of the PRC1 antagonist Usp16 could have a role in regulating also their expansion in Ts65Dn mice."
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