IndraLab

Statements

TGFB1 activates phosphorylated SMAD3. 5 / 5
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"Forced expression of SIRT6 also decreased the rates of cell migration and proliferation, reduced activation of phosphorylated Smad3 induced by TGF-beta1 treatment, suppressed the acetylation level at histone H3K9, and inhibited the transcriptional activity of the c-Jun promotor."
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"Therefore, we suggest that in the cytoplasm, phosphorylated Smad3 induced by TGF-beta1 stimulation increases binding to NFI-C, and results in the degradation of NFI-C."
22195013
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"Importantly, we found that the nuclear translocation of phosphorylated Smad3 induced by TGF-beta1 could be maintained only under Kindlin-1 overexpression, suggesting that Kindlin-1 is required for the nuclear translocation of phosphorylated Smad3."
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"UDCA-LPE also decreased phosphorylated Smad3 and Smad2 directly induced by TGF-beta1."
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"In XREF_FIG, phosphorylated Smad3 was assessed by Western blotting on fibroblasts treated with TGF-beta 1 with and without rapamycin."
22815997