IndraLab
Statements
reach
"Because EGF induced association between EGFR and Brk is EGFR Y1045 phosphorylation dependent (XREF_FIG), we next compared the levels of EGFR-Brk association in CHO cells expressing various combinations of EGFR constructs (wild type, EGFR-Y1045F, and EGFR-Y845F) and Brk constructs (Brk-Y447F and Brk-K219M) to further analyze the roles of Brk kinase activity and Brk induced EGFR Y845 phosphorylation in EGFR-Brk association (XREF_FIG)."
sparser
"Published and unpublished data indicate that the functional difference appears to be due to the fact that EGF stimulates greater EGFR tyrosine phosphorylation at EGFR Tyr1045 than does AREG, resulting in greater EGFR coupling to the ubiquitin ligase c-Cbl and greater EGFR ubiquitination and more rapid EGFR turnover."
"To address this problem, we use quantitative mass spectrometry to analyze dynamic effects of HER2 overexpression on phosphotyrosine signaling in human mammary epithelial cells stimulated by epidermal growth factor (EGF) or heregulin (HRG). [This is from the 'Suplementary Table with Full Data Set\" (http://www.nature.com/msb/journal/v2/n1/suppinfo/msb4100094_S1.html). The cutoff used was a 2.5 fold or greater increase at any of the 5, 10 or 30 minute time points.]"
reach
"Published and unpublished data indicate that the functional difference appears to be due to the fact that EGF stimulates greater EGFR tyrosine phosphorylation at EGFR Tyr1045 than does AREG, resulting in greater EGFR coupling to the ubiquitin ligase c-Cbl and greater EGFR ubiquitination and more rapid EGFR turnover."