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Modified EGF leads to the phosphorylation of EGFR. 6 / 6
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"Finally, the amount of EGFR phosphorylation stimulated by expression of mature EGF is equivalent to that caused by stimulation with 31.6 +/- 5.8 pM soluble EGF (XREF_FIG), a concentration that stimulates a modest level of cell proliferation (XREF_FIG)."
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"Together, these data suggest that EGF expression in the 32D/EGFR/EGF mature cell line is sufficient to stimulate EGFR phosphorylation and turnover; nonetheless, EGF exhibits less intrinsic activity than do the mature or precursor forms of TGFalpha."
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"In contrast, high amounts of EGF induce substantial EGFR phosphorylation, but also EGFR ubiquitination, which favours clathrin independent endocytosis and trafficking towards Lys via Rab7 positive LE for degradation."
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"The amount of EGFR phosphorylation stimulated by expression of mature EGF is approximately 10% of that stimulated by treatment with a saturating concentration of soluble EGF (XREF_FIG, upper panel)."
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"However, syringic acid did not affect UVB induced amphiregulin expression (Data not shown), and there was no change in the levels of the EGF induced phosphorylation of EGFR and Src in HaCaT cells (Dat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The amount of EGFR phosphorylation stimulated by expression of mature EGF is roughly equivalent to that stimulated by expression of mature TGFalpha (XREF_FIG, upper panel)."
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