IndraLab

Statements

BRAF-Y472C activates ERK. 4 / 4
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"As with previously characterized kinase inactivating BRAF mutations, Y472C BRAF expression led to CRAF, MEK, and ERK activation."
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"As before, the expression of Y472C BRAF led to the activation of ERK and increased sensitivity to dasatinib."
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"Y472C BRAF and G466V BRAF both activated MEK and ERK to levels at or above those observed after transfection with wt BRAF."
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"Lung Cancer Cells Expressing Y472C BRAF Express Activated MEK, ERK, and CRAF."
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