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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

RAS bound to EGFR activates ERK. 1 / 1

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"We have demonstrated that transactivation includes a positive feedback circuit that connects proteolytic release of autocrine TGFalpha to EGFR binding to Ras mediated ERK signaling, and that the activity of this circuit can be regulated at different points by diverse inputs."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...