IndraLab

Statements

Ubiquitinated CTNNB1 decreases the amount of CTNNB1. 2 / 2
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"Furthermore, IKKalpha interacted with beta-catenin and mediated beta-catenin stabilization by inhibiting beta-catenin ubiquitination, which in turn stimulated beta-catenin and Tcf-dependent transcription 41 Second, IKKalpha but not IKKbeta, induces CyclinD1 expression, which is identified as a target of Wnt and beta-catenin signaling pathway, also through Tcf activity."
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bel
"It is known that Ser33, Ser37, and Thr41 are phosphorylated by GSK3β, which creates the binding site for β-TrCP and subsequent ubiquitination by the E3 ubiquitin ligase system.[6,7]"
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