IndraLab

Statements

SOS1 binds CBL and GRB2. 6 / 6
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sparser
"In T cells, the SH2 domain of GRB2 binds phosphorylated tyrosines on the adaptor protein LAT and the GRB2 SH3 domains associate with the proline-rich regions of SOS1 and CBL."
16906159
sparser
"As CBL and SOS1 bind to the same region of GRB2, the overexpression of CBL inhibits complex formation between SOS1 and GRB2 underlining the fine-tuning mechanism of accessory proteins by binding other pathway modulators xref ."
34103645
sparser
"What the actual contacts are that drive the interaction of GRB2 with either SOS1 or CBL are outside of the scope of this study."
26079855
sparser
"Instead, as shown by our studies with the SOS1 scrambled mutant, regions outside of the consensus PxxPxR motifs drive the interaction of the complete proline rich region of SOS1 and CBL with full-length GRB2."
26079855
sparser
"In contrast, these same PxxPxR motifs were neither necessary nor sufficient for the high affinity interaction of SOS1 or CBL with full-length GRB2 or required for the in vivo recruitment of SOS1 to the plasma membrane in activated T cells."
26079855
sparser
"To more fully address this prediction, we utilized quantitative biophysical and imaging techniques to examine the binding of GRB2 to its physiological ligands SOS1 and CBL."
26079855