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CTNNB1 inhibits CTNNB1. 301 / 368
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"AXIN and GSK3beta complex subsequently inhibits the phosphorylation of beta-catenin and leads to beta-catenin dissociating from the destruction complex, which causes an accumulation of beta-catenin in the cytoplasm and its eventual translocation into the nucleus."
29029464
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"For example, the phosphorylation of beta-catenin Tyr654 by Src reduces the interaction of beta-catenin and E-cadherin [XREF_BIBR]."
27203386
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"LiCl, an inhibitor of GSK-3beta, could down-regulate the level of phosphorylation of beta-catenin and subsequently induce nuclear translocation of beta-catenin [XREF_BIBR]."
26862734
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"Ectopic expression of USP4 promoted beta-catenin poly-ubiquitination and thus inhibited Wnt induced accumulation of cytosolic beta-catenin and counteracted Wnt induced transcriptional activity."
27128386
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"Conversely, in the presence of Wnt which binds the transmembrane receptor Frizzled (frz), phosphorylation of beta-catenin by the destruction complex is inhibited, causing the accumulation of beta-catenin in the cytoplasm."
23804296
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"In gastric cancer inhibition of MTDH may decrease the level of beta-catenin and inactivate Wnt and beta-catenin pathway through reducing phosphorylation of AKT and glycogen synthase kinase (GSK)-3beta (Ser 9) XREF_BIBR."
22768080
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"Functional analyses in cultured cells, Xenopus, and zebrafish demonstrate that WTX promotes beta-catenin ubiquitination and degradation, which antagonize WNT and beta-catenin signaling."
17510365
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"RT-PCR indicates that overexpression of DACH1 decreases the mRNA expression of beta-catenin and DACH1-siRNA reversed the downregulation of beta-catenin (XREF_FIG)."
30271168
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"Once activated, Dvl inhibits beta-catenin phosphorylation, mediated by Axin [XREF_BIBR] A multiprotein " destruction complex " that includes, adenomatous polyposis coli (APC), axin andglycogen synthase kinase 3beta (GSK3beta), would target and degrade beta-catenin in the absence of Wnt signaling."
27486983
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"In the absence of Wnt ligand, the destruction complex phosphorylates beta-catenin which results in ubiquitinylation mediated proteasomal degradation of beta-catenin."
30123819
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"GSK3beta is an enzyme that phosphorylates the cytosolic beta-catenin to trigger degradation of beta-catenin by the destruction complex."
34026577
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"When considering the triangular relations among EZH2, E-cadherin and beta-catenin, we assumed that MALAT1 could promote the expression level of beta-catenin and, beyond that, increase the effectiveness of beta-catenin by inhibiting the expression level of E-cadherin and consequently decreasing the proportion of E-cadherin-binding beta-catenin."
29290771
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"The results showed that AK045171 promoted the expression of MG53 and the phosphorylation of β-catenin, which decreased translocation of β-catenin into the nucleus."
32087602
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"The GSK/axin/APC destruction complex tightly regulates the cytosolic levels of beta-catenin, thus limiting the ability of beta-catenin to interact with the transcription co-activators, TCF/LEF, and activate target genes."
22522917
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"Phosphorylation of beta-catenin Tyr654 by Src causes a 6-fold reduction in the affinity of beta-catenin for E-cadherin [XREF_BIBR] likely because of the dissociation of the region II from beta-catenin."
27203386
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"The reduced phosphorylation of beta-catenin induces the beta-catenin deposition in nucleus and facilitates downstream genes ' expression, for instance, cyclin D1 and c-Myc, which promotes the metastasis and drug resistance of cells [XREF_BIBR, XREF_BIBR]."
34336161
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"In the signalosomes LRP is phosphorylated resulting in inhibition of GSK-3β which leads to the “β-catenin destruction complex” inactivation and accumulation of β-catenin."
24993527
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"RASAL2 knockdown using siRNA strikingly decreased β-catenin activity/phosphorylation (Ser552) (Supplementary Figure 4A), whereas RASAL2 overexpression activated β-catenin (Supplementary Figure 4B), compared with respective control groups."
35134322
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"Mechanistically, KLF13 decreased expressions of beta-catenin and its target genes, CCND1 and MYC, via triggering autophagic degradation of beta-catenin."
36336731
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"Interestingly, ectopic expression of WT SH3BP4 in DeltaAPC cells suppressed the nuclear beta-catenin level and enhanced perinuclear accumulation of beta-catenin that co-localized with SH3BP4 (XREF_FIG H)."
30811977
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"Diversin recruits CKIepsilon to the beta-catenin degradation complex that consists of Axin and Conductin and GSK3beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin and Tcf signals."
12183362
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"PCP-2 expression also leads to increased membrane bound E-cadherin and greater stabilization of adherens junctions by dephosphorylation of beta-catenin, which could further sequester cytosolic beta-catenin and thus inhibit beta-catenin mediated nuclear signaling."
16574648
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"Pharmacologic inhibition of JNK with SP600125 or by expression of dominant negative JNK (JNKDN) decreased the phosphorylation of beta-catenin and induced translocation of both beta-catenin and E-cadherin to the cell surface."
20858269
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"Β-catenin and Prg4 were both upregulated by the deletion of exon 3 of Ctnnb1 (Fig. 3b)."
31771658
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"Neurological studies reported that DISC1 directly interacts with GSK3beta, and suggested that GSK3beta promotes beta-catenin phosphorylation and ubiquitylation mediated beta-catenin degradation in the proteasome [XREF_BIBR - XREF_BIBR]."
29029423
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"Mechanistically, WDR74 decreased the phosphorylation of beta-catenin and induced nuclear beta-catenin accumulation, activating the Wnt/beta-catenin signaling pathway in CRC cells."
34553072
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"FH535 increased the cytosolic level of beta-catenin in proliferation medium, but decreased basal beta-catenin in differentiation medium."
21970630
eidos
"CK1alpha is a well-characterized beta-catenin kinase that promotes beta-catenin degradation and CK1alpha suppression or inhibition thus leads to upregulation of beta-catenin levels and activation of canonical Wnt pathway [ 124 ] ."
33261128
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"Phosphorylation of beta-catenin by members of the SRC family reduces the association of beta-catenin with E-cadherin and alpha-catenin [XREF_BIBR, XREF_BIBR] increasing the levels of cytoplasmic beta-catenin and translocation to the nucleus, where it interacts with the TCF/LEF transcription factor, resulting on the activation of target genes [XREF_BIBR]."
33503805
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"Of note, this suppression of E-cadherin expression also led to a reduction of beta-catenin phosphorylation by GSK-3beta through unknown regulatory mechanisms, thereby enabling the liberated beta-catenin to escape proteasome mediated degradation XREF_BIBR."
20173740
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"However, levels of DeltaN131 beta-catenin expression may not be sufficient to compete with and disrupt the function of endogenous beta-catenin in E-cadherin-based adhesion."
9199178
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"It has been suggested that the phosphorylation of beta-catenin at residues S33, S37 and S45 by GSK3beta and casein kinase I isoform alpha may inhibit beta-catenin activity by degradation of beta-catenin."
32382323
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"Phosphorylation of beta-catenin on tyrosine residue, Y654, has been shown to decrease the affinity of beta-catenin for cadherin XREF_BIBR, XREF_BIBR."
18820693
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"In the presence of Wnt ligand, a receptor complex forms between Frizzled and LRP5/6, and Frizzled is recruited by Dvl which leads to LRP5/6 phosphorylation and Axin recruitment, which in turn disrupts Axin-mediated phosphorylation/degradation of β-catenin, allowing β-catenin to accumulate in the nucleus where it serves as a coactivator for T-cell factor (TCF) to activate Wnt-responsive genes [8,9]."
32702011
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"Overexpression of EphA2 decreased the phosphorylation of β-catenin at Thr41/Ser45 sites that are phosphorylated by CK1α and GSK3β (Fig. 3g, Supplementary Fig. S5C); and inhibited β-catenin ubiquitination (Fig. 3h), suggesting that EphA2 promotes the stabilization of β-catenin."
30451837
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"Phosphorylation of beta-catenin Tyr 654 by Src was shown to negatively affect the interaction with E-cadherin and enhance transcriptional activity of beta-catenin targets [XREF_BIBR, XREF_BIBR]."
18613032
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"The data demonstrate that multivalent integrin engagement results in increased internalization of E-cadherin, inhibition of GSK-3beta, elevated levels of nuclear beta-catenin, increased beta-catenin-regulated promoter activation, and transcriptional activation of Wnt and beta-catenin target genes."
21518759
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"Previous studies have shown that E-cadherin expression can deplete the cytoplasmic beta-catenin levels inhibiting the nuclear beta-catenin signaling and cell growth in an adhesion independent manner XREF_BIBR, XREF_BIBR - XREF_BIBR."
24722213
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"These results demonstrated that PDIA6 overexpression promoted the proliferation of HeLa cells by suppressing the phosphorylation of beta-catenin, thereby inhibiting the degradation of beta-catenin through the ubiquitin-proteasome pathway."
27462866
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"Targeting beta-catenin in hepatocellular cancers induced by coexpression of mutant beta catenin and K-Ras in mice."
27981621
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"In the Wnt-off state of a canonical Wnt and beta-catenin signaling, GSK-3beta is a negative regulator inhibiting beta-catenin activity by phosphorylating the N-terminal of beta-catenin at ser33/ser37/thr41 leading to its degradation in the proteasome."
29784906
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"42 PTPRK also dephosphorylates beta-catenin and negatively regulates the transcriptional activity of beta-catenin."
25263441
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"In the noncanonical Wnt pathway, Ca i +2 signals originating from G protein activity similarly initiate the phosphorylation and destabilization of beta-catenin, albeit in a GSK3beta independent manner, and also deplete nuclear beta-catenin and terminate its transcriptional activity."
21630427
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"Consistently, immunofluorescence staining further confirmed that TIPE1 significantly decreased the expression of beta-catenin and induced more beta-catenin distributing to the membrane in BGC823 cells."
28994231
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"GSK3beta is a significant cancer control molecule; it controls the degradation of beta-catenin by phosphorylating serine 33/37 of cytosolic beta-catenin, and it may also be involved in crosstalk with the APC, CK1, and Axin complex, which is important in cancer cell proliferation and metastasis 4-7."
24666969
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"In the canonical Wnt signaling cascade, GSK3 phosphorylates β-catenin at S33/S37/T41 and subsequently causes proteasomal degradation of β-catenin."
32033025
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"It is encoded by tumor suppressor gene APC and binds to beta-catenin , which prevents beta-catenin from accumulating in cells and entering the nucleus , and promotes the degradation of beta-catenin ."
32547401
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"In contrast, our ongoing work was focused on several PKC isoforms, whose activation is able to dephosphorylate beta-catenin to prevent beta-catenin from degradation."
25414693
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"Overexpression of Parkin Upregulated beta-Catenin Expression and Increased Autophagy and Parkin Deletion Decreased beta-Catenin and Autophagy."
33043010
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"Mechanistic studies reveal that Acp5 is upregulated by transforming growth factor-beta1 (TGF-beta1) in a TGF-beta receptor 1 (TGFbetaR1)/Smad family member 3 (Smad3)-dependent manner, after which Acp5 dephosphorylates p-beta-catenin at serine 33 and threonine 41, inhibiting the degradation of beta-catenin and subsequently enhancing beta-catenin signaling in the nucleus, which promotes the differentiation, proliferation and migration of fibroblast."
35013220
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"Inactivation of GSK-3beta stabilizes functional beta-catenin, because GSK-3beta-catalyzed phosphorylation of beta-catenin promotes beta-catenin degradation."
26305020
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"The presence of DKK4 protein in culture medium abolished the PGCP knockdown mediated induction of phospho-LRP6 and cell migrations, inactivation of GSK3beta, and increase in beta-catenin levels causing inactivation of Wnt and beta-catenin signaling."
27806330
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"For example, as a key regulator in the Wnt and beta-catenin pathway, GSK-3beta phosphorylates beta-catenin to induce the degradation of beta-catenin in cooperation with adenomatous polyposis coli gene product XREF_BIBR."
26292722
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"Further, our data showed that acetylcarnitine downregulation in CRIP1-overexpressing cells decreased beta-catenin acetylation and promoted nuclear accumulation of beta-catenin, thus facilitating cancer stem-like properties."
35775648
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"When Wnt is present, the axin mediated beta-catenin phosphorylation and degradation is disrupted, allowing beta-catenin to enter and accumulate in the nucleus, where it serves as a transcriptional coactivator for the TCF/LEF family of transcription factors and turns on Wnt responsive target genes."
28114280
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"In the absence of Wnt, beta-catenin is degraded by a multiprotein complex containing Disheveled (Dvl), GSK-3beta, Axin, adenomatous polyposis coli (APC), and casein kinase1alpha (CK1alpha), which phosphorylates beta-catenin and leads to its ubiquitination and proteasomal degradation [XREF_BIBR, XREF_BIBR]."
27835606
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"These data indicate that p300 mediated acetylation of the beta-catenin C terminus is not necessary for and may actually inhibit beta-catenin transactivation."
16543149
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"Glycogen synthase kinase-3beta (GSK-3beta) can phosphorylate and degrade beta-catenin, and negatively regulates Wnt and beta-catenin signal pathway."
29164556
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"Axin, a negative regulator of Wnt, forms a complex with glycogen synthase kinase 3beta, beta-catenin, and adenomatous polyposis coli and promotes GSK3beta dependent phosphorylation of beta-catenin, thereby stimulating degradation of the beta-catenin."
15063782
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"Binding of Wnt ligand to its coreceptors Frizzled (Fz) and low-density lipoprotein (LDL) receptor related protein (LRP) 5/6 activates disheveled (Dvl), which then inhibits GSK-3beta-mediated phosphory[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26047573
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"TGFbeta1 stimulation decreased the phosphorylation levels of beta-catenin and triggered the nuclear accumulation of beta-catenin."
33243628
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"Previous studies have reported that PKG can phosphorylate β-catenin to induce proteasomal degradation of β-catenin (24,26,38)."
34584001
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"It is well known that in non vascular cells, stimulation of Wnt signaling pathway inhibits GSK3beta mediated phosphorylation of beta-catenin and prevents beta-catenin degradation [XREF_BIBR]."
21078118
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"These results confirm that SHP2 is essential for cytoplasmic and nuclear β-catenin expression in TNBC cells and its inhibition depletes β-catenin from these subcellular locations."
34389690
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"Hdac6 deacetylates beta-catenin at lysine 49 (Lys49) to reduce beta-catenin phosphorylation and promote beta-catenin nuclear localization and c-myc induction [XREF_BIBR]."
21615950
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"Their new findings have provided compelling evidence that inhibition of beta-catenin phosphorylation causes subsequent beta-catenin stabilization and that this is the major consequence of Wnt stimulation."
24105937
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"In the present study, we demonstrated that downregulation of WDR74 decreased β-catenin expression in the nucleus and promoted phosphorylation-dependent degradation of β-catenin (Figure 5)."
34553072
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"Furthermore, we reported that β-catenin reduction caused by simulated microgravity (Figure 5b) [14] and overexpression of β-catenin partially attenuated the negative effects of simulated microgravity on osteoblast differentiation (Figure 6)."
32070052
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"Although a previous report proposed that cross talk between the PI3K and WNT and beta-catenin pathways might be prohibited and WNT and beta-catenin-mediated transcriptional activity was not modulated by the activation of the PI3K and Akt pathway XREF_BIBR, our results showed that the oxidation resistant mutant of PTEN, PTEN-C71S, but not wild-type PTEN, as well as PI3K and Akt inhibitor and NAC treatment, reversed AIF knockdown induced expressions of WNT and beta-catenin signaling target genes, supporting that AIF regulates beta-catenin signaling through PTEN-PI3K and Akt pathway."
26415504
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"Here we show that SNG1153 induces beta-catenin phosphorylation and then down-regulates beta-catenin, a crucial component of the WNT pathway, which plays a key role in cancer stem cells."
27281614
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"Allthese results indicated that Curcumin suppressed the beta-catenin expression, and thus induced the activation of the canonical Wnt and beta-catenin signaling."
32714183
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"We also showed that RARRES2 overexpression could enhance beta-catenin phosphorylation at Ser33/Ser37/Thr41, thus promoting the degradation of the beta-catenin protein."
28114280
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"Phosphorylation of beta-catenin at Y654 has been shown to decrease the affinity of beta-catenin for cadherin."
22415718
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"Inhibition of GSK-3-dependent beta-catenin phosphorylation would result in the posttranslational stabilization of beta-catenin and the formation of a free, signaling pool of beta-catenin, as previously described (Yost et al. 1996; Aberle et al. 1997; Orford et al. 1997)."
10427095
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"53 Wnt signaling is suggested to inhibit beta-catenin phosphorylation, thus inducing the accumulation of cytosolic beta-catenin."
27374455
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"Renal specific overexpression of active beta-catenin or loss of APC, which negatively regulates beta-catenin, caused renal cysts in mice."
28409350
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"In this study, we found that Abeta 1-42 (1 muM) activated GSK-3beta by inhibiting phosphorylation on Ser 9, increased the phosphorylation of beta-catenin on Ser 33/37 and Thr 41 and enhanced the nucle[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27131736
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"Yan et al. claimed that tyrosine phosphorylation of beta-catenin leads to greater stimulation of beta-catenin-Tcf-mediated transcription and that PTPRU mediated dephosphorylation of beta-catenin is necessary for PTPRU to inhibit beta-catenin."
26587830
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"In the absence of Wnt ligand stimulation, GSK3beta phosphorylates beta-catenin and causes beta-catenin degradation."
23333798
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"It was additionally revealed that the overexpression of HDAC6 decreased the expression of beta-catenin protein levels which attenuated the canonical Wnt and beta-catenin signaling pathway and suppressed the proliferation of HCC cells."
30546442
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"Similarly, AR79 inhibited beta-catenin phosphorylation, increased nuclear beta-catenin accumulation in prostate cancer and osteoblast cell lines, and increased proliferation of prostate cancer cells in vitro through beta-catenin."
24088787
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"Furthermore, the Ctnnb1 K5-fx/fx thymic phenotype, including the decreased frequency of proliferating thymocytes (total, CD4 - CD8 - DN and CD4 + CD8 + DP; Figure XREF_FIG) and the increased percentage of annexin V labeled apoptotic cells (total and CD4 + CD8 + DP; Figure XREF_FIG), was significantly reversed by the transgenic expression of stabilized beta-catenin in K5 expressing cells."
26101855
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"Co-culture of intestinal epithelial cells with nonpathogenic Salmonella typhimurium leads to the activation of beta-catenin signalling by the AvrA mediated blockade of beta-catenin ubiquitylation XREF_BIBR, XREF_BIBR."
20495574
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"Specifically, FAM83H could decrease the ubiquitylation of beta-catenin, and accordingly activated the effector genes of Wnt/beta-catenin signaling."
36171592
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"Blocked Wnt and beta-catenin signaling is associated with cell cycle arrest in G1 phase and reduced expression of beta-catenin regulated genes, including axin2 and myca."
23036320
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"Likewise, we found that wild-type beta-catenin was efficiently decreased in SNU475 and Hep3B cells by aplykurodin A whereas the amounts of mutant beta catenin lacking N-terminal region was largely unaffected in response to aplykurodin A, suggesting that N-terminal residues of beta-catenin are required for aplykurodin A mediated beta-catenin degradation."
32294900
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"Prevention of β-catenin degradation allows the cytoplasmic level of β-catenin to increase, causing increased translocation of β-catenin into the nucleus, which allows interaction with the TCF/LEF transcription factors leading to enhanced canonical Wnt target gene transcription [99]."
30029495
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"Activation of Wnt signaling decreases the phosphorylation of β-catenin by glycogen synthase kinase 3β (GSK-3β) and thus prevents β-catenin degradation."
31651333
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"Other studies showed that phosphorylation of beta-catenin at Tyr654 and Tyr489 by c-Src and Abelson, respectively, reduced beta-catenin affinity to VE-cadherin allowing dissociation of beta-catenin from VE-cadherin XREF_BIBR, XREF_BIBR."
28057793
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"Demethylation of non phosphorylated beta catenin by KDM2A and KDM2B induces nuclear degradation of beta catenin and loss of Wnt and beta catenin signalling."
28536364
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"In addition, Wnt5a increased the nuclear beta-catenin level and treatment with imatinib or ionomycin, either of which blocks the beta-catenin pathway, reduced the anti-apoptotic activity of Wnt5a, together suggesting the simultaneous involvement of the beta-catenin-mediated pathway in the Wnt5a anti-apoptotic activity."
18407462
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"GSK3beta can phosphorylate beta-catenin at Ser 33 and Ser 37, promoting degradation of beta-catenin by intracellular proteasome, and thus inhibit Wnt and beta-catenin signaling pathway."
29805709
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"SOX30 overexpression or miR-653-5p inhibition significantly reduced beta-catenin expression and downregulated the activation of Wnt and beta-catenin signaling."
31889959
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"However, expression of Sox1-IRES-GFP suppressed TCF/LEF reporter activity, and coexpression of Sox1-IRES-GFP and beta-catenin not only blocked the stimulatory effects of beta-catenin but also signific[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15110721
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"Formation of this complex enhances phosphorylation of APC and beta-catenin by GSK3beta, which enhances beta-catenin degradation."
15821699
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"In the canonical Wnt signaling pathway, GSK3beta phosphorylation of beta-catenin promotes proteasomal targeting and degradation of beta-catenin."
22025562
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"GSK3β phosphorylates Snail, Slug and N-terminal of β-catenin, which causes degradation of β-catenin through the ubiquitin-proteasome degradation pathway."
33294746
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"They showed in HEK293 cells and in human prostate and breast cancer cells, that niclosamide suppressed LRP6 expression and phosphorylation, blocked Wnt3A induced beta-catenin accumulation, and inhibited Wnt and beta-catenin signaling, resulting in induced apoptosis and anti-cancer activity with half maximal inhibitory concentration (IC 50) values less than 1 muM."
27331819
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"Moreover, TAZ knockdown increased endogenous beta-Catenin protein levels and enhanced nuclear accumulation of beta-Catenin after Wnt3A stimulation."
20412773
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"Likewise, in the S3 segment, there was marked loss of beta-catenin from the lateral cell-cell contacts and an increase in the labeling in the cytosol and along the basolateral cell surface."
12791303
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"In contrast, Wnt signaling represses β-catenin phosphorylation, thus inducing β-catenin cytoplasmic accumulation and cytoplasmic-nuclear trafficking."
32758292
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"Chlorogenic acid is known for its antioxidant activity and the prevention of β-catenin phosphorylation, which induces β-catenin degradation."
| PMC
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"Indeed, the recent report that loss of phosphorylation of beta-catenin at Thr41 is sufficient to enhance Wnt and beta-catenin signaling in melanoma cells independent of detected increases in nuclear beta-catenin is entirely consistent with our current observations."
22234612
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"A previous study showed that low Wnt activity in Rb deficient cells was due to E2F1 mediated abrogation of beta-catenin target gene expression and induction of beta-catenin degradation."
29207260
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"Specifically, GSK-3beta controls the degradation of beta-catenin by phosphorylating beta-catenin at Ser 37 and Ser 33."
21686046
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"Furthermore, inhibition of Src kinase activity in cancerous colon blocks the phosphorylation of beta-catenin tyrosine 654 and prevents the dissociation of beta-catenin and E-cadherin XREF_BIBR."
27824116
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"Our data demonstrated that miR-195 overexpression increased beta-catenin phosphorylation, decreased nuclear beta-catenin amount, and thus, suppressed the Wnt and beta-catenin signaling in PTC."
28740507
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"The present results demonstrated that CDC20 silencing led to a significantly decreased protein expression level of beta-catenin and c-Myc, and inhibited the translocation of beta-catenin into the nucleus, suggesting that CDC20 contributes to the development of cSCC through the Wnt and beta-catenin signaling pathway."
30816486
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"Further, BMS-345541 also inhibited beta-catenin ubiquitination (XREF_FIG) and promoted beta-catenin accumulation (XREF_FIG) in nuclei of 3T3-L1 cells."
24799533
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"It was also revealed that nuclear beta-catenin levels were significantly increased while cytoplasmic beta-catenin levels were reduced, which demonstrated the nuclear translocation of beta-catenin by the Der p 1 allergen."
24337587
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"It was found that the PRRX1, p-GSK-3beta, beta-catenin, cyclinD1, N-cadherin and vimentin expressions were markedly abated, while the expression of GSK-3beta, p-beta-catenin, E-cadherin were significantly boosted in MKN-45 and MGC-803 cells transfected with the over-expressed miR-330-3p or under-expressed PRRX1 and vise vista, suggesting that miR-330-3p could inhibit the phosphorylation of GSK-3beta protein by regulating PRRX1 and promote the phosphorylation of beta-catenin to suppress the activation of Wnt and beta-catenin signal pathway, thus inhibiting the EMT of cells."
32368097
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"In the current study, we show for the first time that inhibition of M-cadherin expression by RNAi increases phosphorylation of beta-catenin on the N-terminus at Ser31/37/Thr41, decreases the protein abundance of unphosphorylated active beta-catenin, and impairs the myogenic induction that is caused by either inhibition of GSK-3beta activity or Wnt-3a treatment."
23138569
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"Previous reports have shown that phosphorylation of beta-catenin on tyrosine 654 by Src family kinases greatly decreases the affinity of beta-catenin for cadherins."
16831887
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"When the Wnt signal is activated, the inhibition of beta-catenin phosphorylation leads to increased beta-catenin in cells, allowing increased beta-catenin to enter the nucleus to activate its targets."
32924881
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"GSK3 beta phosphorylated beta-catenin and promoted the degradation of beta-catenin (Clevers and Nusse, 2012)."
26548813
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"Acetaldehyde treatment resulted in phosphorylation of beta-catenin on tyrosine residues, and abolished the interaction of beta-catenin with E-cadherin by a tyrosine kinase dependent mechanism."
17087658
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"Triptolide may downregulate β-catenin expression by inducing GSK3β-mediated β-catenin degradation."
33893396
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"In this pathway, inhibition of beta-catenin phosphorylation by GSK3beta triggers beta-catenin stabilization and its accumulation in the cytoplasm and subsequently in the nucleus where beta-catenin acts as co-activator for the TCF7 and LEF1 transcription factors."
20654575
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"SBSN-2 in ESCC cell lines increased the activity of WNT and beta-catenin signalling pathway, which resulted in TCF/LEF transcriptional activity, nuclear translocation and reduced phosphorylation of WNT and beta-catenin, and increased transcript levels of WNT / beta-catenin signalling regulated genes such as AXIN2, MYC, CCND1, FRA1, MMP7 and JUN.."
33477529
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"Loss-of-function mutations in APC or Axin essentially mimic Wnt activation by preventing GSK3beta mediated phosphorylation of beta-catenin, which allows beta-catenin to accumulate to high levels in both cytoplasmic and nuclear compartments XREF_BIBR."
20419129
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"The binding of Wnt ligand to its receptors inhibits beta-catenin phosphorylation, which allows beta-catenin to escape from degradation."
27411302
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"Normally, Axin is part of an intracellular protein complex that facilitates the phosphorylation of beta-catenin by glycogen synthase kinase 3 (GSK3), thereby targeting beta-catenin for ubiquitin dependent proteolytic degradation."
19072724
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"Consequently, the phosphorylation of beta-catenin by GSK3 is blocked, which enables beta-catenin to accumulate and function as a transcriptional co-activator in the nucleus to operate a transcriptional switch."
31822591
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"For example, XREF_BIBR) show that the glycoprotein 90K has antitumour activity in CRC cells suppressing Wnt and beta-catenin signalling by ISGylation dependent ubiquitination of beta-catenin when interacting with CD9 and CD82."
21772334
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"With heterozygous deletion of Klf5, levels of beta-catenin in the Apc Min /+ setting are reduced to WT levels, resulting in reduced beta-catenin activity as reflected in reduced expression of transcriptional targets including Ccnd1 and c-Myc."
19435907
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"As detailed below, phosphorylation of beta-catenin at two critical tyrosine residues, tyrosine 142 and tyrosine 654, has been shown to disrupt the E-cadherin and beta-catenin adhesion complex with concomitant beta-catenin nuclear activity."
18492263
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"These observations indicate that OLFM4 can directly downregulate endogenous beta-catenin level and antagonize Wnt3a induced regulation of beta-catenin."
26973250
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"Wnt signaling pathway can inhibit GSK-3-mediated phosphorylation of beta-catenin allowing beta-catenin to the nucleus, where the interaction of beta-catenin with TCF family transcription factors regulates gene expression [XREF_BIBR]."
25980581
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"Furthermore, the expression levels of Dax1 were also down-regulated when beta-catenin expression decreased in the cultured testis cells treated with quercetin (XREF_FIG and XREF_FIG) or DKK-1 (XREF_FIG and XREF_FIG), suggesting Dax1 is probably the downstream gene of beta-catenin."
25549092
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"STAT3 paradoxically stimulates beta-catenin expression but inhibits beta-catenin function."
25348333
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"Beta-catenin methylation inhibits beta-catenin ubiquitinoylation and finally drives the activation of Wnt and beta-catenin signaling [XREF_BIBR]."
29262600
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"Mechanistically, WDR74 decreased the phosphorylation of β-catenin and induced nuclear β-catenin accumulation, activating the Wnt/β-catenin signaling pathway in CRC cells."
34553072
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"GSK3β phosphorylates β-catenin and promotes β-catenin degradation [58]."
30285728
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"AXIN2, a direct Wnt target and negative regulator, is known to augment the GSK3beta mediated phosphorylation of beta-catenin by several thousand fold, greatly increasing beta-catenin degradation 39."
29030569
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"This process keeps the cytoplasmic beta-catenin level low thereby preventing the translocation of beta-catenin into the nucleus."
27590724
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"Inhibition of TRPV4 in BMSCs cultured on TNT-100 reduced the expression of osteoblastic genes and the gene expression and protein levels of NFATc1 and Wnt3a and beta-catenin and also decreased nuclear translocation of NFATc1 and beta-catenin (all vs uninhibited BMSCs)."
33417804
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"Tyrosine phosphorylation of beta catenin and Tiam 1 by Src and Src and FAK complex suppresses the association of beta catenin with E-cadherin and disrupts the integrity of adherens junctions, a critical step in epithelial to mesenchymal transition [XREF_BIBR - XREF_BIBR]."
24522479
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"We found that β-catenin-370aa physically interacted with GSK3β, which can phosphorylate β-catenin and thus trigger the degradation of β-catenin."
31027518
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"Western blot showed that silencing Prrx2 expression inhibited the expression of beta-catenin in breast cancer cell nucleus and down-regulated the activity of Wnt and beta-catenin signaling pathway."
32234171
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"Since GSK3 is a kinase within the beta-catenin destruction complex, which could phosphorylate Axin bound beta-catenin and the phosphorylated beta-catenin is then ubiquitinated and targeted for rapid destruction by the proteasome, preventing activation of beta-catenin target genes XREF_BIBR, XREF_BIBR, GSK3 can act as a negative regulator of beta-catenin."
29497056
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"In the absence of Wnt, levels of beta-catenin in the cytoplasmic pool are low due to targeted degradation of beta-catenin."
16683072
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"Wnt signaling is suggested to inhibit beta-catenin phosphorylation, thus inducing the accumulation of cytosolic beta-catenin, which associates with the TCF/LEF (T cell factor and lymphocyte enhancer f[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11955436
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"Knockdown of PCAT1 regulated miR-329 and Wnt10b axis to attenuate beta-catenin expression and nucleus translocation to inhibit Wnt and beta-catenin signaling."
32339605
reach
"CK1 and GSK3 sequentially phosphorylate beta-catenin to induce the ubiquitination and proteasomal degradation of beta-catenin [XREF_BIBR]."
33291655
reach
"Beta-catenin overexpression reversed Wnt and beta-catenin pathway activation and resulted in progressive development of dilated cardiomyopathy [XREF_BIBR]."
33468190
reach
"EZH2 methylates beta-catenin to suppress the ubiquitination of beta-catenin, thereby allowing beta-catenin to activate Wnt signaling to sustain the self-renewal of HCC CSCs [XREF_BIBR]."
33808647
reach
"This ART induced beta-catenin and E-cadherin redistribution may help cancer cells decrease drug resistance and promote apoptosis of SKM-1 cells by inhibiting the hyperactive Wnt and beta-catenin pathway."
26078714
reach
"In vitro, silencing of RAGE expression in 16HBE cells also disrupted TDI induced beta-catenin nuclear translocation and downregulated genes downstream of beta-catenin."
29656209
reach
"Our data showed that, PP up-regulated p-S33/37/T41 β-catenin expression, which is necessary to degrade β-catenin under the control of ubiquitin [23, 58]."
34642308
reach
"In the presence of WNT ligand, phosphorylation of beta-catenin is attenuated, resulting in the nuclear accumulation of beta-catenin and the regulation of transcription."
22215675
reach
"XREF_BIBR, XREF_BIBR Because phosphorylated beta-catenin is more prone to ubiquitination and degradation, inhibition of beta-catenin phosphorylation increases the stability of beta-catenin."
23640485
reach
"Axin promotes the formation of a complex comprising itself, glycogen synthase kinase-3beta (GSK-3beta), adenomatous polyposis coli (APC) and beta-catenin, which in turn enhances the phosphorylation of[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12185851
reach
"In agreement, there was a dramatic loss of beta-catenin from both the cytoplasm and cell periphery upon VE-cadherin depletion."
22398721
reach
"Increased expression of beta-catenin can induce the transcriptional activation of TCF/LEF and beta-catenin silence by siRNA leads to decreased colonosphere formation."
24481453
reach
"GSK3 phosphorylates beta-catenin at S33/S37/T41, leading to proteasome mediated degradation of beta-catenin."
29207259
reach
"Moreover, FGF19 knockdown or miR-520e overexpression decreased the expression of beta-catenin and suppressed the transcriptional activity of Wnt and beta-catenin signaling."
30826062
reach
"Furthermore, TOPORS-AS1 increased beta-catenin degradation and inhibited the expression of CTNNB1, suppressing the Wnt and beta-catenin signaling."
33820921
reach
"Following Wnt induction, the Wnt and beta-catenin signaling pathway is activated and the degradation process of beta-catenin phosphorylation is inhibited, resulting in intracellular accumulation of beta-catenin."
33760186
reach
"In addition, we found that FZD8 overexpression in PCa cells dramatically decreased phosphorylation levels of beta-catenin and potentiated beta-catenin stability."
28602974
reach
"In the Wnt signaling pathway, where the main target is beta-catenin, active GSK3beta phosphorylates beta-catenin at the N-terminal region and enhances beta-catenin degradation, thereby preventing the association of beta-catenin with nuclear transcription factors and activation of target gene expression such as cyclin D1 and c-myc."
22034072
reach
"We also found that these opposing effects on Wnt activation can be explained by the finding that HIF-1alpha depletion not only decreases the beta-catenin protein levels in cells and decreases the nuclear beta-catenin levels but also induces the sequestration of beta-catenin at the cell membrane by E-cadherin."
25396735
reach
"One of the mechanisms by which GSK3beta can mediate cell death is by phosphorylation of beta-catenin in the cytosol, leading to the rapid degradation of beta-catenin by APC complex XREF_BIBR XREF_BIBR."
26822034
reach
"Hong et al demonstrated that TiO 2 NPs downregulated the protein level of Wnt3a and beta-catenin, and inactivated Wnt3a and beta-catenin signaling pathway to block development of neurons [XREF_BIBR]."
33534781
reach
"Nevertheless, the non phosphorylation of beta-catenin at Thr41/Ser37/Ser33 has decreased which explained the downregulation of total beta-catenin."
33015050
reach
"We found that niclosamide was able to suppress LRP6 expression and phosphorylation, block Wnt3A induced beta-catenin accumulation, and inhibit Wnt and beta-catenin signaling in HEK293 cells."
22195040
reach
"Alternatively, HGF might influence cell-cell associations in adherens junctions by inducing phosphorylation of beta-catenin thereby decreasing associations of beta-catenin with E-cadherin [37]."
10854688
reach
"Furthermore, miR-29b mimics potently repressed Wnt7b and beta-catenin protein expression in HASMCs, whereas miR-29b anti-miR increased their expression, indicating miR-29b indeed negatively regulates Wnt7b and beta-catenin signaling."
29195902
reach
"Protein-kinase-C-mediated beta-catenin phosphorylation negatively regulates the Wnt and beta-catenin pathway."
17093267
reach
"Both excessive and insufficient beta-catenin levels may impair the homeostasis of articular chondrocytes by enhancing pathological maturation and apoptosis, respectively; loss- and gain-of-functions of beta-catenin cause apoptosis at the center of the joint and chondrocyte maturation at the periphery, depending on the vascularity."
22646092
reach
"PGE2, in turn, reduces phosphorylation of beta-catenin and activates beta-catenin signaling, which contributes to the cell proliferation."
25557876
reach
"Phosphorylation of beta-catenin by GSK-3beta leads to the instability of beta-catenin, reducing translocation of beta-catenin into the nucleus, which can be associated with tumorigenesis."
26431581
reach
"Abnormal beta-catenin expression leads to the inability of cells to degrade beta-catenin by phosphorylation and ubiquitination, resulting in its accumulation."
33086930
reach
"Both FAK and Src were phosphorylated and there was a loss of nuclear beta-catenin after growing cells on VN coated plates."
19998373
reach
"Beta-Catenin Phosphorylated at Threonine 120 Antagonizes Generation of Active Beta-Catenin by Spatial Localization in trans-Golgi Network."
22511927
reach
"Prostaglandin E2 catalyzed by COX-2, in conjunction with G protein coupled receptors such as EP2, EP4 and LGR5, cause inactivation of glycogen synthase kinase 3beta to decrease the inhibitory phosphorylation of beta-catenin thereby enhancing beta-catenin and Wnt signaling to promote the stem like property of CSCs [XREF_BIBR - XREF_BIBR]."
28009990
reach
"3.2 1,25 (OH) 2 D 3 represses mRNA expression of the beta-catenin target gene of Gli1 but induces the beta-catenin target gene PADI1 in vitro."
24239508
reach
"Wnt signaling inhibits beta-catenin phosphorylation, thus inducing the accumulation of cytosolic beta-catenin, which then associates with the TCF/LEF family of transcription factors to activate Wnt an[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12398896
reach
"Active GSK-3β can prevent transcription of β-catenin target genes by stimulating the degradation of β-catenin protein and promoting the destruction of nuclear phosphorylated β-catenin."
33718039
reach
"Active Wnt signaling inhibits the phosphorylation of beta-catenin by GSK-3beta by a mostly unknown mechanism, thus preventing the degradation of beta-catenin."
11136974
reach
"In addition, the expression of the beta-catenin armadillo domain disrupted the recruitment of beta-catenin to N-cadherin."
25713069
reach
"The activation of Wnt signaling inhibits the stimulatory effect of Axins on β-catenin phosphorylation and allows β-catenin to move to the nucleus (9)."
22422036
reach
"FRAT1 and FRAT2 belong to the GSK-3-binding protein family, inhibit GSK-3-mediated β-catenin phosphorylation and degradation, promote nuclear translocation of β-catenin, and activate Wnt/β-catenin signaling pathway [44]."
32123519
reach
"In this study, we showed that M. alba L. root bark extracts (MRBE) suppressed β-catenin response transcription (CRT), which is aberrantly activated in various cancers, by promoting the degradation of β-catenin."
34584036
reach
"GSK-3beta regulates cytoplasmic beta-catenin levels via phosphorylation and ubiquitin mediated proteasome degradation of beta-catenin."
22475572
reach
"Mechanistically, Presenilin1 promoted the direct phosphorylation of beta-catenin at the 45 site and indirect phosphorylation at the 33/37/41 site, then decreased the stabilized part of beta-catenin and hindered its translocation from the cytoplasm to the nucleus."
32046730
reach
"When unstimulated (“Wnt OFF”), the canonical Wnt transcriptional effector β-catenin is degraded by the proteasome after phosphorylation by the β-catenin destruction complex and ubiquitination by β-TrCP (Axin2, APC, CK1, and GSK3; Figure 5)."
31828974
reach
"Moreover, knockdown of USP20 increases beta-catenin polyubiquitination, which enhances beta-catenin turnover and cell sensitivity to chemotherapy."
29867130
reach
"The formation of the beta and catenin complex is then inhibited and beta-catenin levels in the cytoplasm increase, resulting in beta-catenin translocation to the nuclear and transcriptional activation of target genes (Rudnicki and Williams, 2015; Nusse and Clevers, 2017)."
33409280
reach
"Nuclear beta-catenin levels decrease during differentiation, overexpression of beta-catenin or inhibition GSK3beta activity results in more Pax7 + / MyoD - cells, and depletion of beta-catenin by RNAi enhances differentiation [XREF_BIBR]."
20098319
reach
"Although this was counterintuitive, there was in fact an increase in ser9 phoshorylated GSK3beta, which represents its inactive form, thus indicating that loss of beta-catenin led to an increase in in[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17101329
reach
"Thus, SS can increase the phosphorylation of beta-catenin to trigger protein degradation and can also suppress the synthesis of beta-catenin."
21505183
reach
"These results suggested that EphA2 destabilizes the β-catenin destruction complex by promoting the interaction between Dvl2 and Axin1; and reduces the phosphorylation of β-catenin, thereby preventing its ubiquitination and promoting β-catenin nuclear accumulation."
30451837
reach
"In addition to directly phosphorylating beta-catenin on Y654 and Y142, FGF signaling can also directly activate beta-catenin signaling through the PI3K-AKT pathway, which acts to prevent beta-catenin degradation by inhibiting GSK-3beta, and by phosphorylating beta-catenin on Ser552, which helps to drive beta-catenin to the nucleus."
25470458
reach
"Mechanistically, HOXB4 inhibited cervical tumorigenesis by repressing the transcription of beta-catenin, thereby inhibiting Wnt and beta-catenin signaling pathway activity."
33479226
reach
"JNK mediated beta-catenin signaling inhibition increases the protein level of proapoptotic Bax by regulating the JNK and beta-catenin pathway, which is negatively correlated with the effect of antiapoptotic Bcl-2 (XREF_FIG)."
27247127
reach
"Conversely, insufficient levels of beta-catenin impede the response to Wnt stimulation and also disrupt the second essential role of beta-catenin in the formation and maintenance of adherens junctions, which are crucial for epithelial tissue integrity [XREF_BIBR - XREF_BIBR]."
24105937
reach
"Furthermore, Curcumin was found to decrease beta-catenin expression and induce the inactivation of Wnt and beta-catenin signaling."
32714183
reach
"SG upregulated the expression of AXIN1 and p-beta-catenin, and suppressed the level of APC, phosphorylation of GSK-3beta, and translocation of beta-catenin."
| PMC
reach
"We further demonstrated that SNG1153 induced beta-catenin phosphorylation and down-regulated beta-catenin."
27281614
reach
"Several studies demonstrated that beta-catenin and TCF4 binds directly to the ZEB1 and Slug promoter and activates their transcriptions XREF_BIBR XREF_BIBR We observed nuclear accumulation of beta-catenin in TCTP overexpressing LLC-PK1 cells using subcellular fractionation and immunofluorescence techniques (XREF_FIG), and diminished nuclear beta-catenin in TCTP downregulated melanoma cells (XREF_FIG)."
25622969
reach
"Wnt antagonists like APC, SFRP1/2, CDH1, and activator β-catenin (CTNNB1), along with the increased nuclear accumulation of β-catenin, played a crucial role in the prognosis of breast cancer and had significant clinical as well as prognostic importance [47]."
| PMC
reach
"Beta-catenin is negatively regulated by glycogen synthase kinase 3beta (GSK-3beta) which phosphorylates beta-catenin leading to its degradation."
30104481
reach
"In addition, the decrease in FOXR2 expression markedly reduced the protein levels of beta-catenin, cyclinD1 and c-Myc and hence inactivated the Wnt and beta-catenin pathway in NSCLC cells."
29634928
reach
"In the absence of the Wnt signal, GSK3beta, together with axin and adenomatous polyposis coli protein (APC), forms a complex that phosphorylates beta-catenin, inducing beta-catenin degradation via the proteasome."
33332393
reach
"MALAT1 could bind to CTNNB1 promoter region and recruit methyltransferase to promote CTNNB1 promoter methylation, thereby inhibiting CTNNB1."
30909750
reach
"It was previously well documented that Axin2, a beta-catenin and TCF signaling target molecule, could enhance the phosphorylation of beta-catenin and induce proteasomal degradation of beta-catenin, fo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24975844
reach
"The consequent reduction of beta-catenin phosphorylation and degradation allows beta-catenin to accumulate in the cytoplasm, associated with its translocation to the nucleus."
23015196
reach
"Niclosamide and silibinin inhibit LRP6 expression and phosphorylation, block Wnt3a induced beta-catenin accumulation, and inhibit Wnt and beta-catenin signaling in HEK293 cells, prostate cancer PC-3 and DU145 cells, and breast cancer MDA-MB-231 and T-47D cells [XREF_BIBR, XREF_BIBR]."
26369691
reach
"The T120 phosphorylation causes accumulation of beta-catenin in the trans-Golgi network and decreases nuclear beta-catenin involvement in Wnt signaling [XREF_BIBR]."
26764245
reach
"Singh et al. [XREF_BIBR] found that EGCG increases phosphorylation of beta-catenin on Ser33/37 residues through activation of CK1 and GSK-3beta, thereby reducing accumulation of nuclear beta-catenin, in skin cancer cells."
25352148
reach
"Blockading the Wnt and beta-catenin pathway by DKK1 could low the expression of Wnt5a and beta-catenin, followed by down-regulation of UCH-L1 at protein levels (XREF_FIG)."
27571062
reach
"S45 phosphorylation of beta -catenin is a priming site for subsequent S33/S37/T41 phosphorylation by GSK3 beta and is both necessary and sufficient to initiate beta -catenin degradation (Liu et al., 2[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17208333
reach
"PKC was activated by A23187 treatment and subsequently phosphorylated N-terminal serine (Ser) residues of beta-catenin, which promoted beta-catenin degradation."
17093267
reach
"Furthermore, IKKepsilon phosphorylates beta-catenin and inhibits the activation of beta-catenin signalling."
28523736
reach
"Upon Wnt activation, GSK3beta 's phosphorylation of beta-catenin is inhibited, which allows nuclear translocation of beta-catenin."
22701343
reach
"KLF13 inhibited beta-catenin expression via triggering the autophagic degradation of beta-catenin."
36336731
reach
"Additional experiments revealed that TOPORS-AS1 increased the phosphorylation of beta-catenin and suppressed the expression of CTNNB1, disrupting the Wnt and beta-catenin pathway."
33820921
reach
"Consequently, the expression of beta-catenin was induced by UIRI injury but inhibited by treatment with AMD3100, suggesting the role of CXCR4 in beta-catenin activation."
| PMC
reach
"Phosphorylation of Ser and Thr residues in beta-catenin will trigger proteasomal degradation of beta-catenin [XREF_BIBR]."
27738331
reach
"Under normal conditions, beta-catenin is degraded in the cytoplasm by the active GSK3beta dependent degradation complex (un phosphorylated) which usually phosphorylates beta-catenin at Ser 33/37 / Thr 41."
32474680
reach
"25 Phosphorylation of beta-catenin by GSK3beta causes rapid degradation of beta-catenin, whereas inhibition of GSK3beta leads to beta-catenin accumulation."
24912492
reach
"This suggests that pyrvinium treatment, which decreases cellular oncogenic potential, inhibits beta-catenin transcription and downregulates potentially critical beta-catenin targeted oncogenes."
28695795
reach
"The current data show that knockdown of Fascin in QBC939 cells activated GSK3beta, increased the phosphorylation of beta-catenin, and decreased its nuclear localization by targeting the beta-catenin destruction complex."
27680563
reach
"Here, we report that a long form of cFLIP (cFLIP-L) inhibits beta-catenin ubiquitylation and increases endogenous cytosolic beta-catenin, which results in translocation of beta-catenin into nuclei and induction of beta-catenin-dependent gene expression in cFLIP-L-expressing cells."
15367663
reach
"The formation of the beta and catenin complex is then inhibited and beta-catenin levels in the cytoplasm increase, resulting in beta-catenin translocation to the nuclear and transcriptional activation of target genes."
33409280
reach
"Then, inhibition of beta-catenin phosphorylation raises the levels of beta-catenin in the cell and allows beta-catenin to enter the nuclei to bind to the transcription factor TCF/LEF, thereby initiating transcription of downstream target genes [XREF_BIBR]."
33712069
reach
"Meanwhile, DIXDC1 could inhibit the phosphorylation of beta -catenin and promote the translocation of beta -catenin to the nucleus through stabilizing beta -catenin [7]."
27498060
reach
"XREF_BIBR Mutations that over-activate the transcription of Wnt and beta-catenin target genes are completely dependent on transcriptionally active nuclear beta-catenin, hence disrupting the transcriptional activity of beta-catenin is of great therapeutic interest."
25524068
reach
"Wnt signaling is suggested to inhibit beta-catenin phosphorylation, thus inducing the accumulation of cytosolic beta-catenin, which associates with the TCF/LEF (T cell factor and lymphocyte enhancer factor) family of transcription factors to activate Wnt and beta-catenin-responsive genes [XREF_BIBR - XREF_BIBR]."
26919254
reach
"These results suggest that the anti-carcinogenetic effects of supplemental calcium and vitamin D 3 may, in part, depend on the ability of these agents to favorably modulate the expression of APC, beta-catenin, and E-cadherin and thus, possibly, inhibit proliferative beta-catenin signaling."
22964475
reach
"However, the authors reported that tyrosine phosphorylation of beta-catenin does not change its binding affinity to LEF-1 nor enhances cyclin D1 transactivation, a nuclear target of beta-catenin and L[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20840866
reach
"The in vitro results indicate that stimulation of the CaSR, by Ca (2+) or by the calcimimetic R-568, produced a striking and time dependent decrease in the phosphorylation of beta-catenin at Ser 552 and Ser 675, two amino acid residues that promote beta-catenin transcriptional activity."
22094462
reach
"Another interesting finding was that Gsk3b, which leads to phosphorylation of beta-catenin and stimulates beta-catenin degradation was lower in CKD animals fed 0.6% phosphate than those fed 1.2% phosphate diet, again suggesting that dietary phosphate is involved in the regulation of Wnt and beta-catenin signaling."
24236156
reach
"Lucidin 3-methyl ether induced β-catenin phosphorylation at Ser33/Ser37/Thr41 residues and promoted proteasomal degradation of β-catenin via a GSK-3β-independent mechanism, thereby downregulating Wnt3a-induced β-catenin response transcription (CRT)."
35196641
reach
"We found that cantharidin and other PP2A inhibitors suppressed the migration of pancreatic cells through the Wnt and beta-catenin pathway by phosphorylation and degradation of beta-catenin."
24926961
reach
"Canonical Wnt signaling, where it phosphorylates beta-catenin to signal the degradation of beta-catenin, is a well studied GSK3beta pathway."
27909397
reach
"We found that select stabilized beta-catenin clones were capable of robustly activating the TOPFLASH reporter system in an inducible manner, whereas beta Engrailed clones suppressed beta-catenin signa[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15265686
reach
"Furthermore, beta-catenin phosphorylation was induced, which targets beta-catenin for ubiquitination and proteasomal degradation."
29520277
reach
"AR79 inhibited beta-catenin phosphorylation, increased nuclear beta-catenin accumulation in PCa and osteoblast cell lines and increased proliferation of PCa cells in vitro through beta-catenin."
24088787
reach
"Epistasis experiments indicate that MOCA acts to reduce the levels of nuclear beta-catenin, increase the levels of membrane bound beta-catenin, and enhances cell-cell adhesion."
18716063
reach
"Several groups demonstrated that PKC activation phosphorylated N-terminal serine residues of beta-catenin, which promoted beta-catenin degradation."
25414693
reach
"Interestingly, loss of beta-catenin expression disrupted cell-cell adhesion in S26 cells and increased the nuclear accumulation of beta-catenin in S18 cells after 6 hours of suspension."
27083052
reach
"Notably, knockout of SIRT2 increased beta-catenin acetylation (XREF_FIG D, bottom panel), which stabilizes beta-catenin and enhances beta-catenin signaling, XREF_BIBR suggesting that SIRT2 inhibits beta-catenin through regulation of beta-catenin deacetylation."
31954883
reach
"An analysis of the mechanism associated with apatinib activity demonstrated that by interacting with VEGFR2, apatinib decreased p-Src, p-Akt, and p-GSK3beta levels, which further increased beta-catenin ubiquitination and reduced the nuclear translocation of beta-catenin."
33154652
reach
"This observation is not surprising, given that GSK-3beta is known to play an essential role in the canonical Wnt signal-transduction pathway, initiating proteasomal degradation of beta-catenin by phosphorylating beta-catenin on key residues."
21743491
reach
"TSA treatment increased beta-catenin phosphorylation and inhibited nuclear translocation of beta-catenin in a dose dependent manner (P < 0.01; XREF_FIG)."
28849207
reach
"Normal beta-catenin ubiquitination necessary for constitutive beta-catenin degradation is abolished, allowing the accumulation and translocation of beta-catenin to the nucleus."
14764450
reach
"We reasoned that a SFK inhibitor, which prevents phosphorylation of beta-catenin tyrosine residues, might block the dissociation of the cadherin and catenin complex and increase the extent of membrane localization of beta-catenin, thus inducing epithelial differentiation of hPSCs."
23527294
reach
"On the contrary, when Wnt ligand binds to Fz receptor, beta-catenin phosphorylation is inhibited allowing beta-catenin to accumulate into the nucleus where it works as a LEF1 co-activator for inducing Wnt responsive genes."
33674551
reach
"Loss of membrane or cytoplasmic JUP activates EGFR, which induces phosphorylation of AKT and GSK3beta to inhibit phosphorylation of beta-catenin, thus induces nuclear localization of beta-catenin and promotes EMT of GC cells to acquire an advanced invasion potential."
33364056
reach
"Binding of Wnt to the Frizzled receptor blocks phosphorylation of beta-catenin by glycogen synthase kinase 3 (GSK3), allowing beta-catenin to accumulate and translocate to the nucleus where it binds to TCF/LEF (T-cell factor and lymphoid enhancer factor) transcription factors to modulate expression of target genes [XREF_BIBR]."
29186899
reach
"In its activated form, GSK-3beta forms a catalytically active complex that phosphorylates beta-catenin inducing ubiquitylation and proteasomal degradation of beta-catenin."
26664962
reach
"ASIC1a knockout not only reduced total beta-catenin expression levels but also significantly inhibited the nuclear accumulation of beta-catenin in both liver cancer cells."
27462920
reach
"In normal cells, APC activates glycogen synthase kinase 3β (GSK3β) which in turn phosphorylates N-terminal serine/threonine residues of β-catenin, mediating β-catenin degradation through ubiquitination."
35537038
reach
"In the presence of Wnt signaling, the binding of LRP5/6 and FZD inhibits the activity of the Axin complex and the phosphorylation of beta-catenin, allowing beta-catenin to enter the nucleus, and then bind to TEF and TCF to form a complex, which then recruits cofactors to initiate downstream gene expression."
33589595
reach
"IF analysis was also performed to investigate the influence of Parkin; the results revealed that Parkin overexpression increased the expression of β-catenin while Parkin knockdown significantly decreased β-catenin (Figure 3C)."
33043010
reach
"In order to degrade β-catenin, β-catenin should be initially phosphorylated at its residue Ser45 by CK1, and subsequently be phosphorylated at its residues Ser33, Ser37, and Thr41 by GSK3."
31920959
reach
"Interestingly, the depletion of APCDD1 increased the expression of beta-Catenin and the active form of beta-Catenin in PCI cells, but decreased the expression of beta-Catenin and the coefficient activ[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25592970
reach
"The β-catenin (CTNNB1) mutation causes deregulation of β-catenin degradation and results in β-catenin nuclear accumulation."
32158762
reach
"Inhibition of GSk3β and β-catenin Phosphorylation by phospho-AKt reduces the degradation of β-catenin, and then β-catenin converging in nucleus promotes cell proliferation and inhibits apoptosis by binding transcription factors."
32676386
reach
"The inhibition of AHR in vitro and in vivo increased beta-catenin levels and stimulated the binding of beta-catenin on myelin gene promoters."
29351992
reach
"The level of beta-catenin is negatively regulated by a scaffolding complex, consisting of Axin, adenomatous polyposis coli (APC) and glycogen synthase kinase 3beta (GSK3beta), which targets beta-catenin for degradation through the ubiquitination and proteasome dependent pathway."
29183322
reach
"As expected, the GSK3beta inhibitor lithium chloride (LiCl) decreased beta-catenin phosphorylation and activated Wnt signaling, significantly increasing beta-catenin and TCF4 reporter activity, wherea[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27717711
reach
"Major et al. demonstrated that APC membrane recruitment 1 (Amer1), also known as WTX (Wilms ' tumor suppressor X chromosome), formed a complex with beta-catenin and APC (adenomatous polyposis coli) to promote beta-catenin ubiquitination and degradation, which antagonized the Wnt and beta-catenin signaling pathway [XREF_BIBR]."
32365332
reach
"FGF-2 treatment increased FGFR1 and beta-Catenin protein, reduced the level of p-beta-Catenin and increased activated-beta-Catenin in aged HMDPCs."
26332075
reach
"In the absence of Wnt ligand, β-catenin is usually degraded by the proteosome system including axin, glycogen synthase kinase 3 beta (GSK3β), and casein kinase 1, while binding of Wnt to a frizzled receptor blocks the activity of destruction complex to degrade β-catenin in the presence of Wnt ligand and so β-catenin is translocated into nucleus [13]."
30201862
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"Moreover, the mechanism analysis showed that suppression of ATF3 could lead to an increase the expression of beta-catenin and promote beta-catenin transfer to the nucleus, and might be affected by EGFR/AKT/GSK3beta signaling."
33816467
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"These data demonstrate that enforced expression of Prickle-1 down-regulates Dvl3 and beta-catenin protein levels and inhibits Wnt and beta-catenin activity through the Dvl3-Axin/GSK3beta/APC/beta-cate[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17030191
reach
"SNG1153 induced β-catenin phosphorylation and downregulated β-catenin [101]."
| PMC
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"Wnt could abolish beta-transducin repeats containing proteins (beta-TrCP) recruitment to phosphorylated beta-catenin preventing beta-catenin from ubiquitination and degradation itself XREF_BIBR, XREF_BIBR."
28656063
reach
"The suppressive beta-catenin and TCF signaling caused by SOX1 was not caused by a change in the level of nuclear beta-catenin."
23927962
reach
"The data demonstrated that the reduction in tumor development is caused by the ability of SIRT1 to deacetylate beta-catenin and promote cytoplasmic localization of the nuclear localized oncogenic form of beta-catenin."
19173036
reach
"Besides, ectopic expression of HACE1 down-regulated the protein level of beta-catenin and inhibited the activity of the Wnt and beta-catenin signaling pathway."
29673126
reach
"Intriguingly, experiments conducted by Firestein et al. [XREF_BIBR] demonstrated that SIRT1 deacetylates beta-catenin, a major etiological driver of colorectal malignancies, and suppresses the ability of beta-catenin to trigger transcription and drive cell growth and division."
28636886
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"Mechanistically, we found that Capn4 can decreased beta-catenin ubiquitination to enhance the protein stability of beta-catenin in GC cells."
32777225
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"BCR-ABL phosphorylation of beta-catenin impaired the ability of beta-catenin to bind the GSK-3 and Axin destruction complex."
23778311
reach
"GSK-3β inhibitors antagonize β-catenin phosphorylation and degradation, allowing β-catenin to then accumulate in the nucleus and propagate Wnt signals.As such, organoids were incubated in control media for 7 days and 24 h after switching the media to NC/HC they were incubated in the presence or absence of the GSK-3β inhibitor CHIR99021 (CHIR, 20nM)."
| DOI
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"Consistently, in vitro phosphorylation and binding assays demonstrated that Src can directly phosphorylate p120 and beta-catenin with markedly different outcomes : while beta-catenin phosphorylation at Y654 reduced beta-catenin affinity for an E-cadherin cytosolic domain, p120 phosphorylation increased E-cadherin binding [XREF_BIBR]."
26556953
reach
"MNK inhibition via genetic small interfering RNA (siRNA) knockdown or pharmacologic inhibitor effectively decreased phosphorylation of eIF4E and beta-catenin, leading to reduced beta-catenin activity and transcript levels of Wnt target genes in cervical cancer cells."
31327462
reach
"Kaur et al. demonstrated ALCAM expression in OSCC and correlated with E-Cadherin and beta catenin expression by IHC and concluded that there is a significant loss of E-cadherin and beta-catenin membrane expression in relation to ALCAM expression in early precancerous stage (dysplasia), their sustained deregulation in OSCCs and correlation with aggressive tumor behaviour and poor prognosis, underscoring their potential as candidate biomarkers for disease prognosis."
27601825
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"Moreover, betacatenin expression was significantly reduced in both compartments in response to SP600125 (p < 0.01), further supporting that the release from 14-3-3sigma directs cytoplasmic betacatenin towards degradation, concurrently precluding betacatenin nuclear import even in the presence of activated BCR-ABL1 TK."
26147002
reach
"Since beta-catenin levels were reduced in 1205Lu-Vc cells, we examined phosphorylation of beta-catenin at threonine residue 41 and serine residue 45, which target beta-catenin for ubiquitin mediated degradation."
20738806
reach
"LINC00675 expression causes a significant increase of β-catenin, and LINC00675 knock-down increases the phosphorylation of β-catenin, which causes degradation of β-catenin in the cytoplasm and nucleus."
32758292
reach
"Axin forms a complex with glycogen synthase kinase-3beta (GSK-3beta) and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin, thereby stimulating the degradation of beta-catenin."
10196136
reach
"GSK-3β inhibits Wnt signalling by promoting β-catenin phosphorylation and then inducing the degradation of β-catenin mediated by E3 ligase."
34980884
reach
"Mechanistic studies reveal that methylation of arginine residue 93 in β-catenin decreases the activity of β-catenin."
35089423
reach
"For examples, LMP1 protein of Epstein-Barr virus (EBV) inhibited SIAH1 gene expression in B lymphoma cells by up-regulating beta-catenin expression and increase the accumulation of beta-catenin in the nucleus."
29593670
reach
"GSK3beta dependent phosphorylation of beta-catenin promotes beta-catenin degradation."
30792401
sparser
"Mechanism analysis revealed that the Wnt/β-catenin pathway was activated by up-regulating the expression of β-catenin and inhibiting the protein degradation of β-catenin in NSE-overexpressing SCLC cells, and played a key role in promoting EMT, migration and invasion of SCLC cells."
33618068
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"Elevation of ROR2 increased protein expression of E-cadherin and cytoplasmic beta-catenin but decreased protein abundance of vimentin, MMP-9, and nuclear beta-catenin in PCa cells."
32415173
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"Mechanistically, KLF13 down-regulated β-catenin expression through triggering the autophagic degradation of β-catenin."
36336731
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"These activities are may lead to the phosphorylation of beta-catenin and target the phospho beta-catenin to proteosomal degradation, which essentially suppressed the Wnt and beta-catenin signaling pathway and expression of its target gene, cyclin D1."
29433490
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"In this complex, beta-catenin is phosphorylated by both GSK3beta and CK1alpha, triggering the ubiquitination and subsequent degradation of beta-catenin by the proteasome [XREF_BIBR, XREF_BIBR]."
25996495
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"The tyrosine (Tyr) phosphorylation of VE-cadherin has been reported to cause a loss of the ability of VE-cadherin to bind beta-catenin, while the Tyr phosphorylation of beta-catenin has been demonstrated to decrease the affinity of beta-catenin for the cadherin and increase its turnover at junctions."
25452781
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"By co-treating cells with cycloheximide and MG-132, we proved that CANA promoted proteasomal degradation of beta-catenin protein by increasing phosphorylation of beta-catenin, and CANA-induced inactivation of protein phosphatase 2A was identified being responsible for this effect."
31142735
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"Silencing of LRRFIP1 up-regulated phosphorylation of beta-catenin and decreased its nuclear localization by targeting the beta-catenin destruction complex."
26047573
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"Embelin strongly induced phosphorylation of beta-catenin on Ser 33/37/Thr 41 and might promote beta-catenin degradation."
26252009
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"As revealed in this study, PANK1 phosphorylates the N-terminal serine and threonine residues of β-catenin, promoting degradation of β-catenin through the ubiquitination pathway (Figure 7F)."
35280671
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"Studies have also demonstrated that the phosphorylation of tyrosine 654 from beta-catenin by SRC reduces the association of beta-catenin with E-cadherin and alpha-catenin [XREF_BIBR, XREF_BIBR]."
33503805
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"Quercetin treatment in these TNBC cells induced morphological alterations, DNA fragmentation, and caspase-3 activation, in addition to decreased protein expression of lipogenic enzyme FasN, anti-apoptotic Bcl-2, β-catenin, and reduced nuclear accumulation of β-catenin, indicating a quercetin-mediated inhibition of the Wnt/β-catenin signaling in TNBCs [177]."
30248941
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"In control embryos, the GFP tagged beta-catenin localized robustly to dorsal nuclei and the plasma membrane; however, levels of nuclear beta-catenin were significantly diminished in rapgef5 morphants [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29290587