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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

MEK binds KRAS and RAF1. 2 / 2

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"Indeed, PD0325901 increased the interaction between MEK1/2 and C-Raf in KRAS mutant tumor cells, although not in BRAF mutant tumor cells xref ."

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"Our results indicate that TLN-4601 decreases activated K-Ras (K-Ras-GTP) and Raf-1, which are associated with the inhibition of K-Ras-induced phosphorylation of MEK kinase."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...