IndraLab
Statements
reach
"Genomic alterations included in the PRESSING panel were investigated as previously reported, XREF_BIBR thus exploring several uncommon anti-EGFR resistance mechanisms beyond RAS and BRAF mutations (ie, HER2 amplification and activating mutations; MET amplification; NTRK/ROS1/ALK/RET rearrangements; PIK3CA exon 20 mutations, PTEN inactivating mutations, AKT1 mutations)."
reach
"In conclusion, here we demonstrate that PTEN and INPP4B loss of expression, PIK3CA hotspot mutations, and AKT1 mutations are found in a subset of pure high-grade DCIS and high-grade DCIS adjacent to IBC, that the prevalence of alterations affecting these genes vary more according to the ER/HER2 subtype of DCIS than to its association with synchronous IBC."
reach
"The vast majority of cases (69% of pure DCIS and 75% of DCIS adjacent to IBC) harboring PTEN or INPP4B loss of expression, or PIK3CA or AKT1 mutations, displayed pAKT expression, whereas pS6 expression was found in 6% and 21% of pure DCIS and DCIS adjacent to IBC harboring these molecular aberrations."