IndraLab

Statements

CTNNB1 binds LEF1 and SMAD4. 2 / 2
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"Interestingly, Nishita et al. recently demonstrated that Smad4 forms a complex with β-catenin and Lef1, which regulates the expression of genes required for the formation of the organizer in Xenopus [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12651222
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"The two pathways were found to converge at the promoter of Xtwn , where Smad4, β-catenin, and Lef1 form a complex and bind to adjacent regulatory elements to co-regulate Xtwn expression."
19002158