IndraLab

Statements

WNT3A binds CTNNB1 and LEF1. 5 / 5
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"The ubiquitinated LEF1 accelerates the interaction between β-catenin and LEF1, which is further heightened after Wnt3a treatment."
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"We compared the ability of OSTM1 and OSTM1ΔC to regulate the Wnt3a-induced binding of β-catenin to Lef1 ( Fig. 6 )."
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"Norcantharidin reduces 80% of Wnt3a-induced β-catenin binding with lymphoid enhancer factor/T-cell factor protein [ xref ]."
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"Β-catenin binding to Lef1 increased in cells treated with Wnt3a ( Fig. 6 , compare lanes 1 and 2)."
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"Overexpression of OSTM1 intensified, while OSTM1ΔC inhibited, the Wnt3a-stimulated interaction of β-catenin with Lef1, suggesting that OSTM1 may function as a mediator of this critical protein complex[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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