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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

MTORC2 decreases the amount of IRS1. 4 / 4

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"Activation of mTORC2 downregulates the levels of IRS1 via Fbw8."

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"Kim et al. reported that mTORC2 negatively regulates IRS-1 levels by regulating the stability and localization of F-box/WD repeat containing protein 8 (Fbw8), the substrate targeting subunit of the cullin-7 (CUL7) E3 ligase complex [XREF_BIBR]."

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"Thus, increased IRS-1 levels upon mTORC2 disruption are not due to enhanced transcription or translation."

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"Silencing of mTORC2 components using siRNA (small interfering RNA) also enhanced IRS-1 levels."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...

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Statements

MTORC2 decreases the amount of IRS1. 4 / 4

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