IndraLab

Statements

TP53 binds TRIM28 and MDM2. 7 / 7
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"Moreover, the formation of TRIM28-MDM2-p53 complex is enhanced by class I MAGE proteins (MAGE-A, MAGE-B and MAGE-C protein families), which are highly expressed in various cancers [ xref ]."
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"Treatment with actinomycin D, but not with camptothecin, augmented the interaction of p53 with Mdm2 and KAP1."
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"TRIM28 interacts with MDM2 resulting in an enhanced deacetylation of p53 and a reduced transcriptional activity [ xref ]."
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"MAGE proteins bind to KAP1 and enhance formation of the KAP1, MDM2, and p53 complex, leading to suppression of p53 mediated apoptosis and promotion of tumor cell survival."
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"MAGE proteins bind to KAP1 and enhance formation of the KAP1-MDM2-p53 complex, leading to suppression of p53-mediated apoptosis and promotion of tumor cell survival ( xref )."
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"Kap1 also interacts with Mdm2 and p53 ( xref )."
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"Our earlier findings, for instance, show that TRIM28 may interact with MDM2 to influence the levels of the tumor suppressor p53 and this may account for significantly poorer 5-year overall survival and 5-year ‘recurrence-free’ survival seen in TRIM28 high ratio colorectal cancer patients [ xref ]."
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