IndraLab

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TGFB1 bound to its activates SMAD3. 2 / 2
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"It is now clear that after binding to its receptors, TGF-beta1 activates its downstream signaling pathway, Smad 2 and Smad3, to mediate fibrosis, which is negatively regulated by Smad7, an inhibitor of TGF-beta signaling, via the ubiquitin-proteasome degradation mechanism XREF_BIBR, XREF_BIBR."

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"Once activated, TGF-beta1 binds its receptors and then activates its downstream signaling mediators of Smad3, to exert its biological activities [XREF_BIBR - XREF_BIBR]."