IndraLab

Statements

RPS6KB1 activates RPS6. 64 / 64
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"In turn S6K1 phosphorylates and activates S6 ."
24287118
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"Another important step for BDNF-stimulated dendritic protein synthesis is the phosphorylation of p70S6K, which ultimately activates the ribosomal protein S6 leading to 5’-oligopyrimidine tract-containing mRNAs translation ( xref )."
23467348
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"A knockin mouse carrying mutations at all phosphorylation sites in the primary s6k substrate, ribosomal protein s6 (rps6), has provided insight into the physiological role of this protein phosphorylation event. Of the many known substrates of s6k1, it is rps6 that has been shown to be directly involved, via its phosphorylation, in controlling cell size."
15809305
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"The kinase S6K1 then activates rpS6 [46,71]."
31548505
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"P70S6K phosphorylates and activates ribosomal protein S6 (S6), a component of the 40S ribosomal subunit [10], and phosphorylates the eukaryotic initiation factor 4B (eIF4B), a regulator of protein syn[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24440085
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"Inhibitors of PI 3-kinase or the mammalian target of rapamycin (mTOR) fully blocked p70 S6 kinase activation, implying that this kinase is controlled by PI 3-kinase and mTOR."
10733102
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"Both RSK and S6K1 phosphorylate and activate the ribosomal subunit S6, which is essential for translation."
22079331
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"mTORC1 phosphorylates and modulates the activity of the serine/threonine ribosomal protein S6 kinase 1 (S6K1), which, in turn, phosphorilates and activate S6, a ribosomal protein involved in translation XREF_BIBR - XREF_BIBR."
24303008
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"This transitory effect of rapamycin on PKCalpha and PKD phosphorylation differs from the dephosphorylation kinetics of the p70S6K target pS6, and correlates well with DGKzeta activation."
26302180
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"The phosphorylation of p70 S6 kinase (S6KB1) by mTORC1 also leads to activation of the ribosomal protein S6 and the eukaryotic translation initiation factor 4B (eIF4B)."
28284028
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"However, S6K1 blockade with the selective inhibitor LY2584702 caused a stronger inhibition of pS6 at all time points assessed."
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"S6K1 activates the ribosomal protein S6 (S6), a component of the 40S ribosomal subunit, and the elongation initiation factor 4B (eIF4B) [7,8] ."
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"In support of these findings, p70 S6 kinase, which targets the ribosomal subunit S6 also in this subnetwork, has been found to act as an alternate route for downstream signaling when Akt is inhibited [XREF_BIBR]."
29211761
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"S6K1 may phosphorylate and activate 40S ribosomal protein S6."
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"Phosphorylation of 4EBP1 results in its release from eIF4E and promotes cap dependent translation, whereas phosphorylation of p70S6K activates the ribosomal S6 protein to enhance translation of ribosomal proteins and elongation factors."
24165795
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"mTORC2 phosphorylates Akt at serine 473 for its maximum activation, while mTORC1 phosphorylates the S6K1 that activates the ribosomal protein S6 and other proteins to stimulate protein synthesis ( xref )."
31531148
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"Recombinant NEK6 phosphorylates p70 S6 kinase at Thr412 and other sites and activates the p70 S6 kinase in vitro and in vivo, in a manner synergistic with PDK1."
11516946
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"S6K1 activates the ribosomal protein S6 (S6), a component of the 40S ribosomal subunit, and the elongation initiation factor 4B (eIF4B) [7,8]."
24456794
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"P70 S6K1 is activated by two phosphorylation events: phosphorylation on Ser473 by mTOR complex 2 and on Thr308 by PDK1. xref , xref Subsequently, phosphorylated p70 S6K1 activates the ribosomal protein S6 that stimulates the translation of 5′-TOP messenger ribonucleic acids (mRNAs)."
20616901
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"Activated mTORC1 phosphorylates the hydrophobic motif of S6K1, thus sequentially activating S6 to induce ribosome biogenesis [XREF_BIBR]."
29077002
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"S6K1 mediates ribosomal biogenesis by regulating ribosomal S6 (rs6) protein."
29685622
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"Phosphorylated ribosomal kinase activates ribosomal p70S6 kinase protein, which activates the ribosomal 40S protein S6 and eventually promotes the translation of 5′-terminal mRNA and the expression of NKG2DL."
30813924
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"mTORC1 phosphorylates and activates p70S6K at T389 to activate the ribosomal protein S6 via phosphorylation at S235/236 and S240/244."
29448085
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"Considering that (i) p70S6K induces S6 phosphorylation of the 40S ribosomal subunit, an essential condition for protein synthesis; (ii) eIF2 is essential for the initiation of messenger RNA translation process; and (iii) eIF5A and eEF1A play a central role in the elongation of the polypeptidic chain during the transcripts decoding, the data presented here lead us to suppose that a part of T3 induced insulin expression in INS-1E cells depends on the protein synthesis activation at the post-transcriptional level, as these proteins of the translational machinery were shown to be regulated by T3."
22667453
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"Therefore, the phosphorylation status of p70S6K target ribosomal protein S6 (S6RP) was examined, since its phosphorylation sites could be altered by FKBP12-RAPA-mTOR or mTOR-raptor interactions [XREF_BIBR, XREF_BIBR]."
25849663
signor
"A knockin mouse carrying mutations at all phosphorylation sites in the primary s6k substrate, ribosomal protein s6 (rps6), has provided insight into the physiological role of this protein phosphorylation event. Of the many known substrates of s6k1, it is rps6 that has been shown to be directly involved, via its phosphorylation, in controlling cell size."
15809305
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"We observed a potential activation of translation in both the ischemic and non ischemic myocardial territories of the HC group, including lower levels of HIF-1alpha, in conjunction with higher S6K1 levels, which activates the ribosomal protein S6, in the ischemic myocardial territory (XREF_SUPPLEMENTARY)."
19395857
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"Rapamycin suppresses mTORC1 pathway by inhibiting phosphorylation of p70S6 kinase (p70S6K) at Thr389, which in turn no longer activates ribosomal protein S6 and protein synthesis machinery."
28408970
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"As a central serine/threonine protein kinase, mTOR controls protein synthesis via the phosphorylation of two downstream effectors: the p70S6K which activates RP-S6, and the 4E-BP1 which is inactivated by phosphorylation to induce the release of eIF4E [ xref ]."
27105488
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"During terminal muscle differentiation the amount of eIF3f increase xref as well as mTOR and raptor ( xref ), leading to an increase in S6K1 activation and phosphorylation of rpS6 and 4E-BP1."
20126553
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"After being phosphorylated, S6K1 activates rpS6, which is essential for protein translation."
33102482
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"The results showed that S6K1 inhibition strongly suppressed the activation induced increase in pS6 in both WT and S6K2 -/- T cells."
27613697
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"P70S6k can further activate rpS6, which then increases capacity of protein synthesis."
28296942
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"Moreover, mTOR is able to activate the p70S6K (through T389 phosphorylation) which activates the 40S ribosomal protein S6 via phosphorylation at S240/244 [ xref ], a required process for translation and cell growth."
21904669
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"Normally, S6 and eIF4B are activated by p70 S6 kinase, itself regulated by upstream mTOR signaling; eIF4B is also a target of the p90 S6 kinase, regulated by MAPK signaling."
23316192
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"Phosphorylation of p70S6K in turn results in the activation of ribosomal protein S6 (RPS6) and other translational regulators that further enhance translation initiation and elongation."
25849580
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"mTORC1 controls proliferation driving the ribosomal biogenesis, phosphorylating p70S6K to activate RP-S6, and the eukaryotic translation initiation factor 4E binding protein 1 (4E-BP1)."
29207653
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"Phosphorylation of p70 S6K1 further activates and phosphorylates downstream ribosomal S6 protein (rpS6), which plays a role in mRNA translation of proteins including elongation factors and ribosomal proteins."
29109782
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"Phosphorylation of mTOR activates key eukaryotic translation regulators, including p70-S6 kinase (p70S6K, which directly targets ribosomal S6 protein) and the eukaryotic translation initiation factor 4-E binding protein 1 (4E-BP1)."
22859719
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"In contrast, during terminal muscle differentiation, the amount of eIF3f increases as well as mTORC1, leading to an increase in S6K1 activation and phosphorylation of rpS6 and 4E-BP1 [ xref ]."
23354061
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"Zinc induced p70S6K activation could only upregulate translation of total S6 and tau but not global proteins in SH-SY5Y cells."
16364302
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"FSE diets increased growth factor-1 (IGF-1) and target of rapamycin (TOR) mRNA levels from 0% up to 0.04%, 0.04% FSE diets significantly increased growth factor-1 (IGF-1) mRNA levels and S6 kinase-polypeptide 1 (S6K1) mRNA levels compared to the control group."
31499200
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"mTOR also controls translation via phosphorylation of RPS6 by RPS6 kinase (S6K1) which activates ribosomal protein S6 to promote its 40S ribosome function."
26729373
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"Normally, S6 and eIF4B are activated by p70 S6 kinase, itself regulated by upstream mTOR signaling; eIF4B is also a target of the p90 S6 kinase, regulated by MAPK signaling."
23316192
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"In turn S6K1 phosphorylates and activates S6, a ribosomal protein involved in translation xref , xref , xref ."
23056530
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"Overexpression of wild-type (WT) p70S6K1, and particularly F5A-E389-R3A and E389-DeltaCT, abrogated the reduction of p-S6 by rapamycin; however, rapamycin was equally potent in increasing the level of[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28831455
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"Phosphorylation of p70S6K leads to activation of rpS6, which is involved in translation of 5 ' TOP dependent messenger RNAs."
27995152
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"Overexpression of wild-type (WT) p70S6K1, and particularly F5A-E389-R3A and E389-DeltaCT, abrogated the reduction of p-S6 by rapamycin; however, rapamycin was equally potent in increasing the level of p-Akt in these cells transfected with empty vector, WT p70S6K1, or mutant p70S6K1, regardless of whether p70S6K signaling was inhibited or not (XREF_FIG)."
28831455
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"S6K1 phosphorylates and activates S6, a ribosomal subunit involved in initiating protein synthesis machinery."
30150571
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"Sch9 and S6K1 then targets ribosomal protein S6 and other regulators to modulate protein translation initiation and ribosome biogenesis."
25720796
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"To test this prediction, we analyzed S6 phosphorylation in 3T3 cells treated with S6K1 siRNA."
19302577
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"As a central serine/threonine protein kinase, mTOR controls protein synthesis via the phosphorylation of two downstream effectors : the p70S6K which activates RP-S6, and the 4E-BP1 which is inactivated by phosphorylation to induce the release of eIF4E [XREF_BIBR]."
27105488
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"S6K1 and S6K2 phosphorylate and activate the 40S ribosomal protein S6, which promotes protein synthesis through an increased rate of mRNA transcription. xref S6K1 also regulates cell size and progression through the cell cycle, xref − xref in addition to promoting cell survival by inactivating the proapoptotic protein BAD. xref "
25356520
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"Another important step for BDNF stimulated dendritic protein synthesis is the phosphorylation of p70S6K, which ultimately activates the ribosomal protein S6 leading to 5 '-oligopyrimidine tract containing mRNAs translation."
23467348
sparser
"Activated S6K1 activates 40S ribosomal protein (rp) S6 that represents the most extensively studied substrate of S6K1."
32932888
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"P70S6K phosphorylates and activates S6, a ribosomal subunit involved in initiating translation of 5′ terminal oligopyrimidine tract-containing mRNA encoding components of the protein synthesis machinery."
21188109
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"Changes in S6 phosphorylation are associated with activation of the mammalian target of rapamycin (mTOR) signaling cascade; mTOR activates the translational regulator ribosomal protein S6 kinase 1 (S6K1), which in turn activates ribosomal protein S6 by phosphorylation at serine S240/244."
30914932
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"S6K1 may phosphorylate and activate 40S ribosomal protein S6 ."
34007319
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"mTORC1 phosphorylates and activates p70S6K at T389 to activate the ribosomal protein S6 via phosphorylation at S240/244."
19505958
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"XREF_BIBR The observed selective activation of p70 S6 kinase following Tiam1-spinophilin binding is likely a consequence of increased Rac1 association with p70 S6, which was previously reported to enhance p70 S6 activation."
27442895
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"Both RSK and S6K1 phosphorylate and activate the ribosomal subunit S6, which is essential for translation."
22079331
sparser
"P70S6K phosphorylates and activates ribosomal protein S6 (S6), a component of the 40S ribosomal subunit , and phosphorylates the eukaryotic initiation factor 4B (eIF4B), a regulator of protein synthes[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24440085
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"The phosphorylation levels of S6K1 targets rpS6 (ribosomal protein S6) and p-GSK3beta fell rapidly within 5 minutes and stayed low (p-GSK3beta) or undetectable (p-rpS6) for 120 minutes."
26939705
eidos
"p70 ribosomal protein S6 kinase ( p70S6K ) , a signaling protein that functions downstream of mTORC1 , activates ribosomal protein S6 ( rpS6 ) via phosphorylation and enhances protein synthesis [ 12 ] ."
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