IndraLab

Statements

Mutated CTNNB1 activates CTNNB1. 6 / 6
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"Β-catenin hyperactivation in melanoma is rarely caused by mutations of CTNNB1 [101]."
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"Mutation of the CTNNB1 gene causes the β-catenin protein to be unable to be degraded, abnormally aggregate in the cytoplasm, and ectopically transferred to the nucleus [7]."
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"ACPs are driven by somatic mutations of CTNNB1, which causes the β-catenin pathway not to be degraded effectively, accumulates in cells, and further leads to overactivation of the Wnt-β-catenin pathway (24, 25)."
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"Therefore, the mutation of CTNNB1 causes an accumulation of β-catenin in the cytoplasm and subsequently activates downstream effectors, resulting in infinite proliferation [139]."
| PMC
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"The β-catenin positivity is caused by CTNNB1 mutation in chromosome 3p22."
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"CTNNB1 mutations impede β-catenin degradation, provoke nuclear translocation, and promote transcription of target genes."
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