IndraLab

Statements

Vemurafenib binds RAF1. 5 / 5
| 3 2
reach
"To test whether direct binding of PLX to CRAF is required for induction of signaling, we generated a catC carrying a mutation at the gatekeeper position (T421) in the kinase domain (mutations used and their properties are in XREF_SUPPLEMENTARY)."
20179705
reach
"Additionally, vemurafenib has been found to induce the trans-activation of WT-BRAF or CRAF through hetero-dimerization between vemurafenib bound BRAF V600E and WT-BRAF or CRAF."
28174173
reach
"The data suggest that binding of PLX to CRAF induces activation of the enzyme and, subsequently, ERK signaling."
20179705
sparser
"To test whether direct binding of PLX to CRAF is required for induction of signaling, we generated a catC carrying a mutation at the gatekeeper position (T421) in the kinase domain (mutations used and their properties are in xref )."
20179705
sparser
"The data suggest that binding of PLX to CRAF induces activation of the enzyme and, subsequently, ERK signaling."
20179705