IndraLab

Statements

TP53 binds MDM2 and PKM. 6 / 6
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"Interestingly, we found that PKM2 could bind with both p53 and MDM2 (Figure xref and xref )."
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"To study how PKM2 regulated p53 stability and ubiquitination, we next examined whether PKM2 could interact with p53 and MDM2."
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"PKM2 directly binds with both p53 and MDM2, and promotes p53 ubiquitination."
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"PKM2 could directly bind with both p53 and MDM2 and promote MDM2-mediated p53 ubiquitination."
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"In our study, we demonstrated that PKM2 could directly bind with both p53 and MDM2 to form a ternary complex to promote p53 ubiquitination, thereby promoting its degradation (Figure xref )."
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"Reciprocally, p53 also could bind with PKM2 and MDM2 (Figure xref and xref )."
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