IndraLab

Statements

Modified MTOR leads to the phosphorylation of RPS6KB1. 4 / 4
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"To this end, we found that curcumin reduced expression of mTOR, Raptor and Rictor protein and mRNA levels, as well as downstream mTORC1 mediated phosphorylation of p70S6K and 4E-BP1."
19661333
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"In contrast to loss of Tel2 that completely eliminates mTOR, the residual levels of mTOR remaining in the Tel2 2A mutant were sufficient to allow p70S6K phosphorylation."
20864032
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"We found that ectopic expression of constitutively active mTOR increased the basal level of phosphorylation of S6K1, but not Akt, in serum starved Rh30 cells (XREF_FIG), suggesting that the constitutively active mTOR was functional in the cells."
20628002
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"As expected, reductions in raptor or mTOR expression decreased the phosphorylation of S6K1 and a known substrate, eEF2K [17]."
15268862