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PPARG bound to CACUL1 activates cell differentiation. 1 / 1
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"In this study, we found that CACUL1 binds to PPARgamma and represses its transcriptional activity via opposite regulation of SIRT1 (a deacetylase for histone H3K9) and LSD1 (a demethylase for H3K9) at the PPARgamma target promoter, likely resulting in decreased adipogenic differentiation of murine 3T3-L1 preadipocytes and human ADSCs."