IndraLab

Statements


2 | 12 3

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"C/EBPbeta and YY1 directly interact with Smad3 in GE1 cells."

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"Interestingly, physical interaction between YY1 and Smad3 was dramatically induced by PgLPS."

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"YY1 was co-immunoprecipitated with Smad3 and Smad4 (XREF_FIG), consistent with a previous study XREF_BIBR, suggesting that YY1 physically interacts with both Smad3 and Smad4."

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"In contrast, for the interaction between YY1 and Smad3, PgLPS increased YY1 binding to Smad3."

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"C/EBPbeta and YY1 bind and interact with Smad3 to modulate lipopolysaccharide induced amelotin gene transcription in mouse gingival epithelial cells."

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"The C/EBPbeta, YY1 and Smad3 complexes might be crucial player in the defense system of gingival epithelium against periodontal pathogens and inflammation."

sparser
"Interestingly, physical interaction between YY1 and Smad3 was dramatically induced by Pg LPS (Fig.  xref B)."

No evidence text available

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"Here, we report that PgLPS induced physical interactions between C/EBPbeta, YY1 and Smad3 upregulate Amtn gene transcription via mitogen activated protein kinase kinase 1/2 (MEK1/2), phosphatidylinositol 3-kinase (PI3-K) and Smad2/3 pathways in mouse gingival epithelial cells."

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"Interestingly, Smad3 binding to C/EBP1, C/EBP2 and YY1 was increased by PgLPS in a time dependent manner."

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"For regulation of Amtn gene transcription by PgLPS via YY1 and Smad3, immunoprecipitation was carried out to examine whether YY1 and Smad3 binding responded independently or interactively to their own elements in the mouse Amtn gene promoter."

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"In this study we have shown that PgLPS induced Amtn gene transcription that was mediated through C/EBPbeta, YY1 and Smad3 binding to C/EBP1, C/EBP2 and YY1 elements, which was accompanied by physical interaction between C/EBPbeta, YY1 and Smad3."

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"YY1 interaction with Smad3 leads to the repression of miR-29 promoter during myoblasts transdifferentiation into myofibroblasts."

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"To investigate molecular mechanisms for YY1 mediated Foxp3 regulation, we first examined whether YY1 interacts with Smad3 and Smad4 by co-immunoprecipitation (co-IP) experiments."

sparser
"YY1 interaction with Smad3 leads to the repression of miR-29 promoter during myoblasts transdifferentiation into myofibroblasts ( xref )."

No evidence text available

sparser
"In contrast, for the interaction between YY1 and Smad3, Pg LPS increased YY1 binding to Smad3 (Fig.  xref )."