IndraLab

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EGF phosphorylates AKT1 on S473. 5 / 5
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"Co-transfection of let-7b and mCherry-AKT1 led to decreased AKT1 expression, and we found let-7b also prevents the EGF-dependent increase in mCherry-AKT1 S473 phosphorylation."
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"For instances, EGF promotes Ser 473 phosphorylation only in AKT1 in some, but not all, human esophageal squamous cancer cell lines [48] , and exercise activates only AKT1 in rat skeletal muscle [49][MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17825284
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"EGF rapidly phosphorylates Akt-1 at Ser473 with a peak at 15 min and a decrease by 60 min, although it was still higher than controls at 2 hrs."
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"EGF rapidly phosphorylates Akt-1 at Ser473 with a peak at 15 min and a decrease by 60 min, although it was still higher than controls at 2 hrs."
18579759
bel
"Western blotting with the anti-phospho-Akt1 antibody, which recognizes only phosphorylated Ser-473 residue, was performed in human esophageal cancer cell lines (TE-2, TE-5, TE-8, TE-9, TE-10, and TE-12 cells) (top panel). PDGF-treated NIH3T3 cells served as a positive control. The phospho-Akt antibody demonstrated two bands at 60 kDa. The phosphorylation of Akt was enhanced by EGF stimulation in all the esophageal cancer cell lines examined, although TE-5 cells showed high basal phosphorylation of Akt."
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