IndraLab

Statements


Methylated CTNNB1 leads to the deubiquitination of CTNNB1. 2 / 2
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"EZH2 methylates beta-catenin to suppress the ubiquitination of beta-catenin, thereby allowing beta-catenin to activate Wnt signaling to sustain the self-renewal of HCC CSCs [XREF_BIBR]."

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"Importantly, Zhu et al. found that beta-catenin methylation suppressed beta-catenin ubiquitination and stability, leading to Wnt and beta-catenin signaling activation and sustaining tumorigenicity of HCC cell lines XREF_BIBR."