IndraLab

Statements

MTOR phosphorylates RPS6KB1-S6K on T412. 4 / 4
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"RAFT1 phosphorylates p70 (S6k) on Thr 389, a residue whose phosphorylation is rapamycin sensitive in vivo and necessary for S6 kinase activity."
9465032
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"Yet, in the absence of raptor, the ability of mTOR to phosphorylate p70 s6k T389 was still sensitive to inhibition by rapamycin."
23077579
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"MTOR in turn phosphorylates p70 S6K at Thr 389."
23342114
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"Increased mTOR activity enhances Thr 389 phosphorylation of p70S6 kinase (S6K) as an indicative of activation of mTOR signaling, and leads to glomerular hypertrophy in diabetic nephropathy."
22472346