IndraLab

Statements

Modified DUSP6 leads to the phosphorylation of MAPK1. 3 / 3
| 3
reach
"Co-expression of DUSP6 abrogated phosphorylation of wild-type ERK2, kinase impaired ERK2 (ERK2 K54R), ERK2 R191H and endogenous ERK2 (XREF_FIG)."
27760319
reach
"This reduced expression is associated with constitutive activation of MAPK1 and ERK2 and, despite the presence of mutated KRAS, exogenous overexpression of DUSP6 induces dephosphorylation of MAPK1 and ERK2, subsequent suppression of proliferation, and eventual apoptosis of pancreatic cancer cells."
25699241
reach
"Co-expression of DUSP6 abrogated phosphorylation of wild-type ERK2, kinase impaired ERK2 (ERK2 K54R), ERK2 R191H, and endogenous ERK2."
27760319