IndraLab

Statements

Phosphorylated CTNNB1 activates CTNNB1. 3 / 3
| 3
reach
"The phosphorylated beta-catenin in the beta-catenin destruction complex is polyubiquitinated by beta-transducin repeat containing protein, a component of a ubiquitin ligase complex, targeting beta-catenin for rapid degradation by the proteasome."
25788321
reach
"Hence, non phosphorylated beta-catenin is released from the complex and translocates to the nucleus, which allows beta-catenin to interact with the transcription factors TCF/LEF to transactivate target genes such as c-myc, cyclin D1, and CD44."
28918047
reach
"Since GSK3 is a kinase within the beta-catenin destruction complex, which could phosphorylate Axin bound beta-catenin and the phosphorylated beta-catenin is then ubiquitinated and targeted for rapid destruction by the proteasome, preventing activation of beta-catenin target genes XREF_BIBR, XREF_BIBR, GSK3 can act as a negative regulator of beta-catenin."
29497056