IndraLab

Statements

Modified TP53 activates apoptotic process. 10 / 10
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"The authors conclude that high levels of p53 prevent Sod2 expression to enhance apoptosis, whereas low levels of p53 may enhance Sod2 levels to promote a pro survival state."
21434856
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"Ectopic expression of wild-type p53 induced both p21 expression and apoptosis."
9584145
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"Expression of p53 enhances selenite induced superoxide production and apoptosis in human prostate cancer cells."
16489034
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"Overexpression of p53 activates transcription of p53 effector genes, causes growth inhibition and induced apoptosis."
11313982
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"Mutant procaspase-1 also inhibited apoptosis induced by p53 overexpression or doxorubicin treatment, which induce caspase-1 gene expression."
12459463
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"Expression of exogenous p53 in wild-type p53 cells did not induce elevation of Bax levels, arrest in G2 phase, or apoptosis."
9230885
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"DNA damage results in an increase in P53 levels, which is required to initiate a P53 mediated cell cycle arrest and/or apoptosis."
14610316
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"Nutlin 3a treatment of wild type p53 expressing cultured cancer cells increases p53 levels and causes p53 mediated transactivation, cell cycle arrest, and apoptosis [XREF_BIBR]."
22703617
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"Interestingly, over-expression of p53-WT promoted CPT induced PARP-1 degradation and apoptosis, whereas over-expression of p53-S15A or p53-S20A or p53 S46A mutant failed to induce PARP-1 degradation and TUNEL apoptosis after CPT treatment (XREF_FIG and XREF_SUPPLEMENTARY)."
22893124
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"Ectopic expression of wild-type p53 in WEHI 231 cells induced both p21 expression and apoptosis."
9584145