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Resveratrol decreases the amount of IRS1. 10 / 10
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"Resveratrol treatment decreased the basal levels of IRS-1 and the phosphorylated form of protein kinase B (AKT-P), and resulted in a small increase in insulin stimulated AKT-P (XREF_FIG)."

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"Finally, we demonstrate that resveratrol inhibits insulin dependent changes in glucose uptake and glycogen levels and decreases IRS-1 and GLUT4 protein levels, indicating resveratrol represses insulin sensitivity in adipocytes."

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"Resveratrol and 17beta-estradiol significantly inhibited the increase of the blood glucose level and the rise of plasma malondialdehyde in STZ induced diabetic mice, improved the levels of plasma antioxidant capacity and plasma insulin, protected the pancreatic islet cells, and increased the expressions of GLUT4 and IRS-1, but decreased p-ERK expression in skeletal muscle and myocardial tissue."

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"Resveratrol suppressed the mRNA expression of c-Src, Rac1, cdc42, IRS-1, MEKK1, MEKK4, and mitogen activated protein kinase along with the protein levels of c-Src, p-Src, and cdc42 in VSMCs."

No evidence text available